Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 1662270..1663122 Replicon chromosome
Accession NZ_CP093040
Organism Bartonella krasnovii strain 75A_1b

Toxin (Protein)


Gene name VbhT Uniprot ID -
Locus tag MNL06_RS06765 Protein ID WP_241440667.1
Coordinates 1662270..1662947 (-) Length 226 a.a.

Antitoxin (Protein)


Gene name VbhA Uniprot ID -
Locus tag MNL06_RS06770 Protein ID WP_120121200.1
Coordinates 1662934..1663122 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL06_RS06740 (MNL06_06740) 1658057..1659238 + 1182 WP_120121194.1 type IV secretion system protein VirB10 -
MNL06_RS06745 (MNL06_06745) 1659314..1660366 + 1053 WP_120121196.1 P-type DNA transfer ATPase VirB11 -
MNL06_RS06750 (MNL06_06750) 1660473..1660631 - 159 WP_241440665.1 helix-turn-helix domain-containing protein -
MNL06_RS06755 (MNL06_06755) 1661143..1661253 - 111 WP_241436032.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
MNL06_RS06760 (MNL06_06760) 1661424..1662248 - 825 WP_241440666.1 BID domain-containing protein -
MNL06_RS06765 (MNL06_06765) 1662270..1662947 - 678 WP_241440667.1 Fic family protein Toxin
MNL06_RS06770 (MNL06_06770) 1662934..1663122 - 189 WP_120121200.1 antitoxin VbhA family protein Antitoxin
MNL06_RS06775 (MNL06_06775) 1663318..1663566 - 249 WP_120121202.1 HigA family addiction module antitoxin -
MNL06_RS06780 (MNL06_06780) 1663580..1663681 - 102 Protein_1316 Killer protein -
MNL06_RS06785 (MNL06_06785) 1663966..1665336 - 1371 WP_120121203.1 phosphoglucosamine mutase -
MNL06_RS06790 (MNL06_06790) 1665894..1668065 - 2172 WP_120121205.1 ATP-dependent zinc metalloprotease FtsH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(55-152)

Antitoxin

Antitoxin VbhA

(10-56)


Sequences

Toxin        


Download         Length: 226 a.a.        Molecular weight: 25968.47 Da        Isoelectric Point: 6.9268

>T237633 WP_241440667.1 NZ_CP093040:c1662947-1662270 [Bartonella krasnovii]
VEKYKGSGDPYTDPKTGVLYNRFGIKDKATLDRVESTFAYVRSFELMLAAIRGKFDLSYMKEIHRKLFGDIYEWAGEVRL
VDIAKGNSMFASYHQIESYAPKITQQLAKEQYLRGLNMDEFSQRAGYYMGELNALHPFREGNGRTLREFMGQLAREAGYH
ISWKGIEKQEMIEASIAAHFGKSEHLSVLIHKNLIKFTENERDDVTHLGEKISSYIEINKELYEG

Download         Length: 678 bp

>T237633 NZ_LR882498:c2409807-2409490 [Mycobacterium tuberculosis variant microti]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7231.29 Da        Isoelectric Point: 4.8409

>AT237633 WP_120121200.1 NZ_CP093040:c1663122-1662934 [Bartonella krasnovii]
MLSEDEIKRRRFAAKNALASQRLEGLEPDPKVVEQMERVIIGELETSDVIRDYMERVKRGEV

Download         Length: 189 bp

>AT237633 NZ_LR882498:c2410019-2409804 [Mycobacterium tuberculosis variant microti]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References