Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
| Location | 933300..933889 | Replicon | chromosome |
| Accession | NZ_CP093040 | ||
| Organism | Bartonella krasnovii strain 75A_1b | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | - |
| Locus tag | MNL06_RS03800 | Protein ID | WP_120122258.1 |
| Coordinates | 933300..933632 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | - |
| Locus tag | MNL06_RS03805 | Protein ID | WP_241436376.1 |
| Coordinates | 933632..933889 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNL06_RS03780 (MNL06_03780) | 928776..929555 | + | 780 | WP_241440877.1 | hypothetical protein | - |
| MNL06_RS03785 (MNL06_03785) | 930885..931781 | - | 897 | Protein_736 | phage terminase large subunit | - |
| MNL06_RS03790 (MNL06_03790) | 931762..932094 | - | 333 | WP_241436378.1 | hypothetical protein | - |
| MNL06_RS03795 (MNL06_03795) | 932402..933112 | + | 711 | WP_120122259.1 | hypothetical protein | - |
| MNL06_RS03800 (MNL06_03800) | 933300..933632 | - | 333 | WP_120122258.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MNL06_RS03805 (MNL06_03805) | 933632..933889 | - | 258 | WP_241436376.1 | antitoxin | Antitoxin |
| MNL06_RS03810 (MNL06_03810) | 933984..934406 | - | 423 | WP_241440878.1 | hypothetical protein | - |
| MNL06_RS03815 (MNL06_03815) | 934525..934983 | - | 459 | WP_241436488.1 | single-stranded DNA-binding protein | - |
| MNL06_RS03820 (MNL06_03820) | 935374..935457 | + | 84 | WP_241436487.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MNL06_RS03825 (MNL06_03825) | 935474..935767 | + | 294 | WP_034988160.1 | HigA family addiction module antitoxin | - |
| MNL06_RS03830 (MNL06_03830) | 935806..936093 | - | 288 | WP_241440896.1 | hypothetical protein | - |
| MNL06_RS03835 (MNL06_03835) | 936311..936511 | - | 201 | WP_241436374.1 | hypothetical protein | - |
| MNL06_RS03840 (MNL06_03840) | 936584..936802 | + | 219 | Protein_747 | hypothetical protein | - |
| MNL06_RS03845 (MNL06_03845) | 936805..937841 | + | 1037 | Protein_748 | tyrosine-type recombinase/integrase | - |
| MNL06_RS03850 (MNL06_03850) | 937897..938196 | - | 300 | WP_120122206.1 | HigA family addiction module antitoxin | - |
| MNL06_RS03855 (MNL06_03855) | 938212..938403 | - | 192 | Protein_750 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 909007..943690 | 34683 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11853.95 Da Isoelectric Point: 10.5590
>T237632 WP_120122258.1 NZ_CP093040:c933632-933300 [Bartonella krasnovii]
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIGARQGKKMETVPPMIMNEVLAKLATFLT
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIGARQGKKMETVPPMIMNEVLAKLATFLT
Download Length: 333 bp
>T237632 NZ_LR882498:c2373155-2372721 [Mycobacterium tuberculosis variant microti]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9334.59 Da Isoelectric Point: 3.8225
>AT237632 WP_241436376.1 NZ_CP093040:c933889-933632 [Bartonella krasnovii]
MYTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLIVKPQTFPSYTLDELLAQCNPSDDFADEDIEWFDAQPV
GSELL
MYTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLIVKPQTFPSYTLDELLAQCNPSDDFADEDIEWFDAQPV
GSELL
Download Length: 258 bp
>AT237632 NZ_LR882498:c2373416-2373162 [Mycobacterium tuberculosis variant microti]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|