Detailed information of TA system TA237630

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/ParE(toxin)
• Location: 1695621..1696096
• Replicon: chromosome
• Accession: NZ_CP093039
• Organism: Bartonella krasnovii strain B9_5

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: MNL07_RS07185
• Protein ID: WP_120121236.1
• Coordinates: 1695621..1695908 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: -
• Locus tag: MNL07_RS07190
• Protein ID: WP_120121238.1
• Coordinates: 1695908..1696096 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNL07_RS07160 (MNL07_07160)	1690717..1691859	-	1143	WP_120121231.1	OpgC domain-containing protein	-
MNL07_RS07165 (MNL07_07165)	1692135..1692797	+	663	WP_120121233.1	thiamine phosphate synthase	-
MNL07_RS07170 (MNL07_07170)	1693404..1694180	+	777	WP_241436038.1	nucleotide-binding protein	-
MNL07_RS07175 (MNL07_07175)	1694632..1695033	+	402	WP_120122708.1	helix-turn-helix transcriptional regulator	-
MNL07_RS07180 (MNL07_07180)	1695040..1695261	+	222	WP_148255698.1	hypothetical protein	-
MNL07_RS07185 (MNL07_07185)	1695621..1695908	-	288	WP_120121236.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MNL07_RS07190 (MNL07_07190)	1695908..1696096	-	189	WP_120121238.1	antitoxin	Antitoxin
MNL07_RS07195 (MNL07_07195)	1696601..1696969	+	369	WP_120121240.1	helix-turn-helix transcriptional regulator	-
MNL07_RS07200 (MNL07_07200)	1697292..1697704	+	413	Protein_1395	hypothetical protein	-
MNL07_RS07205 (MNL07_07205)	1698908..1699951	+	1044	WP_120121242.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11097.98 Da
• Isoelectric Point: 10.1866

>T237630 WP_120121236.1 NZ_CP093039:c1695908-1695621 [Bartonella krasnovii]
MLPVVWLSSARDDLRQILTYIARENPSAARRMKRFLETSVLPLAEHPYLYRQSERILGLREIIAHPNYLILYRVAANQIE
IVAVVHARREFPTSL

Nucleotide

• Length: 288 bp

>T237630 NZ_LR882498:2259906-2260304 [Mycobacterium tuberculosis variant microti]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 7068.01 Da
• Isoelectric Point: 4.3167

>AT237630 WP_120121238.1 NZ_CP093039:c1696096-1695908 [Bartonella krasnovii]
MKNTLSPFISEFETIEQESSHTAWLRDKVAISLANLSPPIPHDEVMAEMDVIISQLENEQKK

Nucleotide

• Length: 189 bp

>AT237630 NZ_LR882498:2259678-2259905 [Mycobacterium tuberculosis variant microti]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCGACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG