Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
| Location | 823956..824545 | Replicon | chromosome |
| Accession | NZ_CP093039 | ||
| Organism | Bartonella krasnovii strain B9_5 | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | - |
| Locus tag | MNL07_RS03370 | Protein ID | WP_120122258.1 |
| Coordinates | 824213..824545 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | - |
| Locus tag | MNL07_RS03365 | Protein ID | WP_241436376.1 |
| Coordinates | 823956..824213 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNL07_RS03315 (MNL07_03315) | 819354..819635 | + | 282 | WP_120122205.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MNL07_RS03320 (MNL07_03320) | 819651..819950 | + | 300 | WP_120122206.1 | HigA family addiction module antitoxin | - |
| MNL07_RS03325 (MNL07_03325) | 820006..821042 | - | 1037 | Protein_648 | tyrosine-type recombinase/integrase | - |
| MNL07_RS03330 (MNL07_03330) | 821045..821262 | - | 218 | Protein_649 | hypothetical protein | - |
| MNL07_RS03335 (MNL07_03335) | 821335..821535 | + | 201 | WP_241436374.1 | hypothetical protein | - |
| MNL07_RS03340 (MNL07_03340) | 821752..822039 | + | 288 | WP_241436486.1 | hypothetical protein | - |
| MNL07_RS03345 (MNL07_03345) | 822078..822371 | - | 294 | WP_034988160.1 | HigA family addiction module antitoxin | - |
| MNL07_RS03350 (MNL07_03350) | 822388..822471 | - | 84 | WP_241436487.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MNL07_RS03355 (MNL07_03355) | 822862..823320 | + | 459 | WP_241436488.1 | single-stranded DNA-binding protein | - |
| MNL07_RS03360 (MNL07_03360) | 823439..823861 | + | 423 | WP_241436375.1 | hypothetical protein | - |
| MNL07_RS03365 (MNL07_03365) | 823956..824213 | + | 258 | WP_241436376.1 | antitoxin | Antitoxin |
| MNL07_RS03370 (MNL07_03370) | 824213..824545 | + | 333 | WP_120122258.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MNL07_RS03375 (MNL07_03375) | 824733..825443 | - | 711 | WP_241436377.1 | hypothetical protein | - |
| MNL07_RS03380 (MNL07_03380) | 825750..826082 | + | 333 | WP_241436378.1 | hypothetical protein | - |
| MNL07_RS03385 (MNL07_03385) | 826063..826959 | + | 897 | Protein_660 | phage terminase large subunit | - |
| MNL07_RS03390 (MNL07_03390) | 828290..829069 | - | 780 | WP_241436379.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 814157..863422 | 49265 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11853.95 Da Isoelectric Point: 10.5590
>T237628 WP_120122258.1 NZ_CP093039:824213-824545 [Bartonella krasnovii]
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIGARQGKKMETVPPMIMNEVLAKLATFLT
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIGARQGKKMETVPPMIMNEVLAKLATFLT
Download Length: 333 bp
>T237628 NZ_LR882498:c2234932-2234372 [Mycobacterium tuberculosis variant microti]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G
Antitoxin
Download Length: 86 a.a. Molecular weight: 9334.59 Da Isoelectric Point: 3.8225
>AT237628 WP_241436376.1 NZ_CP093039:823956-824213 [Bartonella krasnovii]
MYTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLIVKPQTFPSYTLDELLAQCNPSDDFADEDIEWFDAQPV
GSELL
MYTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLIVKPQTFPSYTLDELLAQCNPSDDFADEDIEWFDAQPV
GSELL
Download Length: 258 bp
>AT237628 NZ_LR882498:c2235270-2234929 [Mycobacterium tuberculosis variant microti]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|