Detailed information of TA system TA237627

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 263914..264506
• Replicon: chromosome
• Accession: NZ_CP093039
• Organism: Bartonella krasnovii strain B9_5

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: J1A4H1
• Locus tag: MNL07_RS01080
• Protein ID: WP_005774031.1
• Coordinates: 264306..264506 (-)
• Length: 67 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: J1KFB1
• Locus tag: MNL07_RS01075
• Protein ID: WP_005774032.1
• Coordinates: 263914..264309 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNL07_RS01045 (MNL07_01045)	258976..260904	-	1929	WP_241436214.1	phage terminase large subunit family protein	-
MNL07_RS01050 (MNL07_01050)	260934..261485	-	552	WP_241436216.1	hypothetical protein	-
MNL07_RS01055 (MNL07_01055)	261867..262448	-	582	WP_241436217.1	hypothetical protein	-
MNL07_RS01060 (MNL07_01060)	262445..262771	-	327	WP_241436219.1	hypothetical protein	-
MNL07_RS01065 (MNL07_01065)	263125..263307	+	183	Protein_207	type II toxin-antitoxin system HicA family toxin	-
MNL07_RS01070 (MNL07_01070)	263328..263750	+	423	WP_144754996.1	type II toxin-antitoxin system HicB family antitoxin	-
MNL07_RS01075 (MNL07_01075)	263914..264309	-	396	WP_005774032.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MNL07_RS01080 (MNL07_01080)	264306..264506	-	201	WP_005774031.1	type II toxin-antitoxin system HicA family toxin	Toxin
MNL07_RS01085 (MNL07_01085)	264571..265017	-	447	WP_241436220.1	hypothetical protein	-
MNL07_RS01090 (MNL07_01090)	265205..266371	+	1167	WP_241436221.1	site-specific integrase	-
MNL07_RS01095 (MNL07_01095)	266581..266781	+	201	WP_007347430.1	DNA-binding protein	-
MNL07_RS01100 (MNL07_01100)	266885..267778	+	894	WP_241436222.1	toprim domain-containing protein	-
MNL07_RS01105 (MNL07_01105)	267778..269352	+	1575	WP_241436224.1	YfjI family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	227357..298824	71467

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-125)

Sequences

Toxin

Protein

• Length: 67 a.a.
• Molecular weight: 7443.82 Da
• Isoelectric Point: 10.9914

>T237627 WP_005774031.1 NZ_CP093039:c264506-264306 [Bartonella krasnovii]
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIALQAGWLKKGEEE

Nucleotide

• Length: 201 bp

>T237627 NZ_LR882498:c2227979-2227560 [Mycobacterium tuberculosis variant microti]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14702.71 Da
• Isoelectric Point: 4.3191

>AT237627 WP_005774032.1 NZ_CP093039:c264309-263914 [Bartonella krasnovii]
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDAEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI

Nucleotide

• Length: 396 bp

>AT237627 NZ_LR882498:c2228248-2227988 [Mycobacterium tuberculosis variant microti]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Structures

Toxin

• AlphaFold DB: J1A4H1

Antitoxin

• AlphaFold DB: J1KFB1