Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/ParE(toxin)
Location 1778804..1779279 Replicon chromosome
Accession NZ_CP093038
Organism Bartonella krasnovii strain B84_4

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag MNL08_RS07535 Protein ID WP_120121236.1
Coordinates 1778804..1779091 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag MNL08_RS07540 Protein ID WP_241439170.1
Coordinates 1779091..1779279 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL08_RS07510 (MNL08_07510) 1773901..1775043 - 1143 WP_120121231.1 OpgC domain-containing protein -
MNL08_RS07515 (MNL08_07515) 1775319..1775981 + 663 WP_120121233.1 thiamine phosphate synthase -
MNL08_RS07520 (MNL08_07520) 1776587..1777363 + 777 WP_241436038.1 nucleotide-binding protein -
MNL08_RS07525 (MNL08_07525) 1777815..1778216 + 402 WP_120122708.1 helix-turn-helix transcriptional regulator -
MNL08_RS07530 (MNL08_07530) 1778223..1778444 + 222 WP_148255698.1 hypothetical protein -
MNL08_RS07535 (MNL08_07535) 1778804..1779091 - 288 WP_120121236.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNL08_RS07540 (MNL08_07540) 1779091..1779279 - 189 WP_241439170.1 antitoxin Antitoxin
MNL08_RS07545 (MNL08_07545) 1779784..1780152 + 369 WP_241439171.1 helix-turn-helix transcriptional regulator -
MNL08_RS07550 (MNL08_07550) 1780475..1780887 + 413 Protein_1465 hypothetical protein -
MNL08_RS07555 (MNL08_07555) 1782091..1783134 + 1044 WP_120121242.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11097.98 Da        Isoelectric Point: 10.1866

>T237626 WP_120121236.1 NZ_CP093038:c1779091-1778804 [Bartonella krasnovii]
MLPVVWLSSARDDLRQILTYIARENPSAARRMKRFLETSVLPLAEHPYLYRQSERILGLREIIAHPNYLILYRVAANQIE
IVAVVHARREFPTSL

Download         Length: 288 bp

>T237626 NZ_LR882498:c2218843-2218547 [Mycobacterium tuberculosis variant microti]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7053.99 Da        Isoelectric Point: 4.3167

>AT237626 WP_241439170.1 NZ_CP093038:c1779279-1779091 [Bartonella krasnovii]
MKNTLSPFISEFETVEQESSHTAWLRDKVAISLANLSPPIPHDEVMAEMDVIISQLENEQKK

Download         Length: 189 bp

>AT237626 NZ_LR882498:c2219091-2218840 [Mycobacterium tuberculosis variant microti]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References