Detailed information of TA system TA237625

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-DUF971
• Location: 971466..972039
• Replicon: chromosome
• Accession: NZ_CP093038
• Organism: Bartonella krasnovii strain B84_4

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: MNL08_RS04065
• Protein ID: WP_120122373.1
• Coordinates: 971731..972039 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: MNL08_RS04060
• Protein ID: WP_120122374.1
• Coordinates: 971466..971750 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNL08_RS04040 (MNL08_04040)	966891..968909	+	2019	WP_241436961.1	portal protein	-
MNL08_RS04045 (MNL08_04045)	968922..969806	+	885	WP_241441153.1	hypothetical protein	-
MNL08_RS04050 (MNL08_04050)	969900..971024	+	1125	WP_120122376.1	N4-gp56 family major capsid protein	-
MNL08_RS04055 (MNL08_04055)	971050..971430	+	381	WP_120122375.1	hypothetical protein	-
MNL08_RS04060 (MNL08_04060)	971466..971750	-	285	WP_120122374.1	putative addiction module antidote protein	Antitoxin
MNL08_RS04065 (MNL08_04065)	971731..972039	-	309	WP_120122373.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MNL08_RS04070 (MNL08_04070)	972114..972821	+	708	WP_120122787.1	hypothetical protein	-
MNL08_RS04075 (MNL08_04075)	972823..974283	+	1461	WP_241436389.1	hypothetical protein	-
MNL08_RS04080 (MNL08_04080)	974283..974708	+	426	WP_241436390.1	hypothetical protein	-
MNL08_RS04085 (MNL08_04085)	974710..975591	+	882	WP_120122370.1	hypothetical protein	-
MNL08_RS04090 (MNL08_04090)	975603..975740	+	138	WP_167309298.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	871677..987112	115435

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-91)

Antitoxin

• Uncharacterized protein HI1420 (13-92)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11857.83 Da
• Isoelectric Point: 9.7095

>T237625 WP_120122373.1 NZ_CP093038:c972039-971731 [Bartonella krasnovii]
MILIHKTIEFDTWLKKLKDKSVKAIILQRVVRLKQGLFGDVKFFHGIGELRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Nucleotide

• Length: 309 bp

>T237625 NZ_LR882498:2216585-2216962 [Mycobacterium tuberculosis variant microti]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10191.69 Da
• Isoelectric Point: 9.6249

>AT237625 WP_120122374.1 NZ_CP093038:c971750-971466 [Bartonella krasnovii]
MKITPFKPEEYLKDIESQKIFLNEALKTGDAAHIADALGIVARAQNMSALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLSVQSSTS

Nucleotide

• Length: 285 bp

>AT237625 NZ_LR882498:2217004-2217453 [Mycobacterium tuberculosis variant microti]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA