Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 926294..926883 Replicon chromosome
Accession NZ_CP093038
Organism Bartonella krasnovii strain B84_4

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MNL08_RS03775 Protein ID WP_120122258.1
Coordinates 926551..926883 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MNL08_RS03770 Protein ID WP_120122257.1
Coordinates 926294..926551 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL08_RS03740 (MNL08_03740) 921576..922763 + 1188 WP_120122252.1 DUF1376 domain-containing protein -
MNL08_RS03745 (MNL08_03745) 922747..923127 + 381 WP_174767382.1 hypothetical protein -
MNL08_RS03750 (MNL08_03750) 923310..923819 + 510 WP_120122253.1 hypothetical protein -
MNL08_RS03755 (MNL08_03755) 924068..924931 + 864 WP_120122254.1 hypothetical protein -
MNL08_RS03760 (MNL08_03760) 925207..925650 + 444 WP_120122255.1 single-stranded DNA-binding protein -
MNL08_RS03765 (MNL08_03765) 925705..926199 + 495 WP_120122256.1 hypothetical protein -
MNL08_RS03770 (MNL08_03770) 926294..926551 + 258 WP_120122257.1 antitoxin Antitoxin
MNL08_RS03775 (MNL08_03775) 926551..926883 + 333 WP_120122258.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNL08_RS03780 (MNL08_03780) 927071..927781 - 711 WP_120122259.1 hypothetical protein -
MNL08_RS03785 (MNL08_03785) 928089..928424 + 336 WP_120122260.1 hypothetical protein -
MNL08_RS03790 (MNL08_03790) 928405..929730 + 1326 WP_120122261.1 phage terminase large subunit -
MNL08_RS03795 (MNL08_03795) 929715..931763 + 2049 WP_120122262.1 portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 871677..987112 115435


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11853.95 Da        Isoelectric Point: 10.5590

>T237624 WP_120122258.1 NZ_CP093038:926551-926883 [Bartonella krasnovii]
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIGARQGKKMETVPPMIMNEVLAKLATFLT

Download         Length: 333 bp

>T237624 NZ_LR882498:c2209839-2209510 [Mycobacterium tuberculosis variant microti]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9346.69 Da        Isoelectric Point: 3.8857

>AT237624 WP_120122257.1 NZ_CP093038:926294-926551 [Bartonella krasnovii]
MYTTKLRKVGGSVMLSIPPVLLDVLHLTENTQVGLAVDNGQLIVKPQTFPSYTLDELLAQCNPSVDFADEDIEWFDAQPV
GSELL

Download         Length: 258 bp

>AT237624 NZ_LR882498:c2210213-2209836 [Mycobacterium tuberculosis variant microti]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References