Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 916099..916672 Replicon chromosome
Accession NZ_CP093037
Organism Bartonella krasnovii strain B1_2_M1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MNL09_RS03965 Protein ID WP_120122373.1
Coordinates 916364..916672 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MNL09_RS03960 Protein ID WP_120122374.1
Coordinates 916099..916383 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL09_RS03940 (MNL09_03930) 911860..913542 + 1683 WP_241436388.1 phage portal protein -
MNL09_RS03945 (MNL09_03935) 913555..914439 + 885 WP_241441153.1 hypothetical protein -
MNL09_RS03950 (MNL09_03940) 914533..915657 + 1125 WP_120122376.1 N4-gp56 family major capsid protein -
MNL09_RS03955 (MNL09_03945) 915683..916063 + 381 WP_120122375.1 hypothetical protein -
MNL09_RS03960 (MNL09_03950) 916099..916383 - 285 WP_120122374.1 putative addiction module antidote protein Antitoxin
MNL09_RS03965 (MNL09_03955) 916364..916672 - 309 WP_120122373.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNL09_RS03970 (MNL09_03960) 916747..917454 + 708 WP_120122787.1 hypothetical protein -
MNL09_RS03975 (MNL09_03965) 917456..918916 + 1461 WP_277623601.1 hypothetical protein -
MNL09_RS03980 (MNL09_03970) 918916..919341 + 426 WP_277623602.1 hypothetical protein -
MNL09_RS03985 (MNL09_03975) 919343..920185 + 843 WP_277623603.1 hypothetical protein -
MNL09_RS03990 (MNL09_03980) 920208..921524 + 1317 WP_277623604.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 838176..951249 113073


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Uncharacterized protein HI1420

(13-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11857.83 Da        Isoelectric Point: 9.7095

>T237622 WP_120122373.1 NZ_CP093037:c916672-916364 [Bartonella krasnovii]
MILIHKTIEFDTWLKKLKDKSVKAIILQRVVRLKQGLFGDVKFFHGIGELRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

>T237622 NZ_LR882498:c1949466-1949077 [Mycobacterium tuberculosis variant microti]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTATCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10191.69 Da        Isoelectric Point: 9.6249

>AT237622 WP_120122374.1 NZ_CP093037:c916383-916099 [Bartonella krasnovii]
MKITPFKPEEYLKDIESQKIFLNEALKTGDAAHIADALGIVARAQNMSALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLSVQSSTS

Download         Length: 285 bp

>AT237622 NZ_LR882498:c1949690-1949463 [Mycobacterium tuberculosis variant microti]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References