Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
| Location | 1027031..1027620 | Replicon | chromosome |
| Accession | NZ_CP093036 | ||
| Organism | Bartonella krasnovii strain B51_4 | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | - |
| Locus tag | MNL10_RS04460 | Protein ID | WP_120122258.1 |
| Coordinates | 1027031..1027363 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | - |
| Locus tag | MNL10_RS04465 | Protein ID | WP_120122257.1 |
| Coordinates | 1027363..1027620 (-) | Length | 86 a.a. |
Genomic Context
Location: 1024788..1025138 (351 bp)
Type: Others
Protein ID: WP_241436930.1
Type: Others
Protein ID: WP_241436930.1
Location: 1025140..1025463 (324 bp)
Type: Others
Protein ID: WP_241436929.1
Type: Others
Protein ID: WP_241436929.1
Location: 1026133..1026843 (711 bp)
Type: Others
Protein ID: WP_120122259.1
Type: Others
Protein ID: WP_120122259.1
Location: 1025622..1025810 (189 bp)
Type: Others
Protein ID: Protein_868
Type: Others
Protein ID: Protein_868
Location: 1027031..1027363 (333 bp)
Type: Toxin
Protein ID: WP_120122258.1
Type: Toxin
Protein ID: WP_120122258.1
Location: 1027363..1027620 (258 bp)
Type: Antitoxin
Protein ID: WP_120122257.1
Type: Antitoxin
Protein ID: WP_120122257.1
Location: 1027715..1028209 (495 bp)
Type: Others
Protein ID: WP_120122256.1
Type: Others
Protein ID: WP_120122256.1
Location: 1028264..1028707 (444 bp)
Type: Others
Protein ID: WP_120122255.1
Type: Others
Protein ID: WP_120122255.1
Location: 1028983..1029846 (864 bp)
Type: Others
Protein ID: WP_120122254.1
Type: Others
Protein ID: WP_120122254.1
Location: 1030095..1030604 (510 bp)
Type: Others
Protein ID: WP_120122253.1
Type: Others
Protein ID: WP_120122253.1
Location: 1030787..1031167 (381 bp)
Type: Others
Protein ID: WP_241440088.1
Type: Others
Protein ID: WP_241440088.1
Location: 1031151..1032296 (1146 bp)
Type: Others
Protein ID: WP_241440089.1
Type: Others
Protein ID: WP_241440089.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNL10_RS04440 (MNL10_04440) | 1024788..1025138 | + | 351 | WP_241436930.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MNL10_RS04445 (MNL10_04445) | 1025140..1025463 | + | 324 | WP_241436929.1 | helix-turn-helix transcriptional regulator | - |
| MNL10_RS04450 (MNL10_04450) | 1025622..1025810 | - | 189 | Protein_868 | hypothetical protein | - |
| MNL10_RS04455 (MNL10_04455) | 1026133..1026843 | + | 711 | WP_120122259.1 | hypothetical protein | - |
| MNL10_RS04460 (MNL10_04460) | 1027031..1027363 | - | 333 | WP_120122258.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MNL10_RS04465 (MNL10_04465) | 1027363..1027620 | - | 258 | WP_120122257.1 | antitoxin | Antitoxin |
| MNL10_RS04470 (MNL10_04470) | 1027715..1028209 | - | 495 | WP_120122256.1 | hypothetical protein | - |
| MNL10_RS04475 (MNL10_04475) | 1028264..1028707 | - | 444 | WP_120122255.1 | single-stranded DNA-binding protein | - |
| MNL10_RS04480 (MNL10_04480) | 1028983..1029846 | - | 864 | WP_120122254.1 | hypothetical protein | - |
| MNL10_RS04485 (MNL10_04485) | 1030095..1030604 | - | 510 | WP_120122253.1 | hypothetical protein | - |
| MNL10_RS04490 (MNL10_04490) | 1030787..1031167 | - | 381 | WP_241440088.1 | hypothetical protein | - |
| MNL10_RS04495 (MNL10_04495) | 1031151..1032296 | - | 1146 | WP_241440089.1 | YdaU family protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 981538..1043320 | 61782 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11853.95 Da Isoelectric Point: 10.5590
>T237620 WP_120122258.1 NZ_CP093036:c1027363-1027031 [Bartonella krasnovii]
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIGARQGKKMETVPPMIMNEVLAKLATFLT
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIGARQGKKMETVPPMIMNEVLAKLATFLT
Download Length: 333 bp
>T237620 NZ_LR882498:1695560-1695877 [Mycobacterium tuberculosis variant microti]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9346.69 Da Isoelectric Point: 3.8857
>AT237620 WP_120122257.1 NZ_CP093036:c1027620-1027363 [Bartonella krasnovii]
MYTTKLRKVGGSVMLSIPPVLLDVLHLTENTQVGLAVDNGQLIVKPQTFPSYTLDELLAQCNPSVDFADEDIEWFDAQPV
GSELL
MYTTKLRKVGGSVMLSIPPVLLDVLHLTENTQVGLAVDNGQLIVKPQTFPSYTLDELLAQCNPSVDFADEDIEWFDAQPV
GSELL
Download Length: 258 bp
>AT237620 NZ_LR882498:1695261-1695563 [Mycobacterium tuberculosis variant microti]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA