Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1027031..1027620 Replicon chromosome
Accession NZ_CP093036
Organism Bartonella krasnovii strain B51_4

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MNL10_RS04460 Protein ID WP_120122258.1
Coordinates 1027031..1027363 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MNL10_RS04465 Protein ID WP_120122257.1
Coordinates 1027363..1027620 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL10_RS04440 (MNL10_04440) 1024788..1025138 + 351 WP_241436930.1 type II toxin-antitoxin system RelE/ParE family toxin -
MNL10_RS04445 (MNL10_04445) 1025140..1025463 + 324 WP_241436929.1 helix-turn-helix transcriptional regulator -
MNL10_RS04450 (MNL10_04450) 1025622..1025810 - 189 Protein_868 hypothetical protein -
MNL10_RS04455 (MNL10_04455) 1026133..1026843 + 711 WP_120122259.1 hypothetical protein -
MNL10_RS04460 (MNL10_04460) 1027031..1027363 - 333 WP_120122258.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNL10_RS04465 (MNL10_04465) 1027363..1027620 - 258 WP_120122257.1 antitoxin Antitoxin
MNL10_RS04470 (MNL10_04470) 1027715..1028209 - 495 WP_120122256.1 hypothetical protein -
MNL10_RS04475 (MNL10_04475) 1028264..1028707 - 444 WP_120122255.1 single-stranded DNA-binding protein -
MNL10_RS04480 (MNL10_04480) 1028983..1029846 - 864 WP_120122254.1 hypothetical protein -
MNL10_RS04485 (MNL10_04485) 1030095..1030604 - 510 WP_120122253.1 hypothetical protein -
MNL10_RS04490 (MNL10_04490) 1030787..1031167 - 381 WP_241440088.1 hypothetical protein -
MNL10_RS04495 (MNL10_04495) 1031151..1032296 - 1146 WP_241440089.1 YdaU family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 981538..1043320 61782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11853.95 Da        Isoelectric Point: 10.5590

>T237620 WP_120122258.1 NZ_CP093036:c1027363-1027031 [Bartonella krasnovii]
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIGARQGKKMETVPPMIMNEVLAKLATFLT

Download         Length: 333 bp

>T237620 NZ_LR882498:1695560-1695877 [Mycobacterium tuberculosis variant microti]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9346.69 Da        Isoelectric Point: 3.8857

>AT237620 WP_120122257.1 NZ_CP093036:c1027620-1027363 [Bartonella krasnovii]
MYTTKLRKVGGSVMLSIPPVLLDVLHLTENTQVGLAVDNGQLIVKPQTFPSYTLDELLAQCNPSVDFADEDIEWFDAQPV
GSELL

Download         Length: 258 bp

>AT237620 NZ_LR882498:1695261-1695563 [Mycobacterium tuberculosis variant microti]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References