Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 682394..683000 | Replicon | chromosome |
| Accession | NC_012622 | ||
| Organism | Sulfolobus islandicus Y.G.57.14 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | D2PIS7 |
| Locus tag | YG5714_RS03580 | Protein ID | WP_012715825.1 |
| Coordinates | 682608..683000 (+) | Length | 131 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | C3NC15 |
| Locus tag | YG5714_RS03575 | Protein ID | WP_009991920.1 |
| Coordinates | 682394..682618 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| YG5714_RS15845 (YG5714_0725) | 678398..678562 | + | 165 | WP_012715820.1 | hypothetical protein | - |
| YG5714_RS03545 (YG5714_0726) | 678552..679634 | + | 1083 | Protein_742 | hypothetical protein | - |
| YG5714_RS03550 (YG5714_0728) | 679650..679958 | - | 309 | WP_012715821.1 | type II toxin-antitoxin system VapC family toxin | - |
| YG5714_RS03555 (YG5714_0729) | 679955..680215 | - | 261 | WP_187146859.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| YG5714_RS03560 (YG5714_0730) | 680592..680828 | + | 237 | WP_009991916.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| YG5714_RS03565 (YG5714_0731) | 680806..681204 | + | 399 | WP_012715823.1 | type II toxin-antitoxin system VapC family toxin | - |
| YG5714_RS03570 (YG5714_0732) | 681472..682203 | - | 732 | WP_012715824.1 | IS1 family transposase | - |
| YG5714_RS03575 (YG5714_0733) | 682394..682618 | + | 225 | WP_009991920.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| YG5714_RS03580 (YG5714_0734) | 682608..683000 | + | 393 | WP_012715825.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| YG5714_RS03585 (YG5714_0735) | 683174..684118 | + | 945 | WP_012715826.1 | IS110 family transposase | - |
| YG5714_RS03590 (YG5714_0736) | 684223..685367 | - | 1145 | Protein_751 | RNA-guided endonuclease TnpB family protein | - |
| YG5714_RS03595 (YG5714_0737) | 685644..686021 | - | 378 | WP_009989379.1 | type II toxin-antitoxin system VapC family toxin | - |
| YG5714_RS03600 (YG5714_0738) | 685987..686241 | - | 255 | WP_009989377.1 | antitoxin VapB family protein | - |
| YG5714_RS03605 (YG5714_0739) | 686401..687126 | - | 726 | WP_012715828.1 | IS1 family transposase | - |
| YG5714_RS03610 (YG5714_0740) | 687234..687785 | + | 552 | WP_012715829.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 681472..687126 | 5654 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 15087.83 Da Isoelectric Point: 8.2957
>T23762 WP_012715825.1 NC_012622:682608-683000 [Sulfolobus islandicus Y.G.57.14]
MKDKEFLFDASALYSLLDYVDKIDLKKIHILTLTFYEIGNVIWKEYYIHKKVKDPITLSILFHKLMRKLNVVEDPPLEGV
MRIAVERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM
MKDKEFLFDASALYSLLDYVDKIDLKKIHILTLTFYEIGNVIWKEYYIHKKVKDPITLSILFHKLMRKLNVVEDPPLEGV
MRIAVERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM
Download Length: 393 bp
>T23762 NC_012622:682608-683000 [Sulfolobus islandicus Y.G.57.14]
ATGAAAGATAAGGAATTCCTATTCGATGCCTCAGCTTTGTACTCGCTTTTAGACTACGTGGATAAAATAGACTTAAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGATAGGTAACGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACTCTTTCGATACTTTTCCATAAATTAATGCGAAAACTTAACGTAGTAGAGGATCCACCTCTTGAGGGAGTA
ATGAGAATTGCCGTAGAAAGGGGTTTGACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGCTGATAAGAAAAGCTAATGCTATTTCATTAAAAGATTTGATAAAAAGTATGTGA
ATGAAAGATAAGGAATTCCTATTCGATGCCTCAGCTTTGTACTCGCTTTTAGACTACGTGGATAAAATAGACTTAAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGATAGGTAACGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACTCTTTCGATACTTTTCCATAAATTAATGCGAAAACTTAACGTAGTAGAGGATCCACCTCTTGAGGGAGTA
ATGAGAATTGCCGTAGAAAGGGGTTTGACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGCTGATAAGAAAAGCTAATGCTATTTCATTAAAAGATTTGATAAAAAGTATGTGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8881.24 Da Isoelectric Point: 5.0355
>AT23762 WP_009991920.1 NC_012622:682394-682618 [Sulfolobus islandicus Y.G.57.14]
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIVMRIKELMRDVSEDDWVRAVRESRDER
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIVMRIKELMRDVSEDDWVRAVRESRDER
Download Length: 225 bp
>AT23762 NC_012622:682394-682618 [Sulfolobus islandicus Y.G.57.14]
ATGTCAGACGTAATAAGCGTAAGGGTTAAGAAAGAGCTGAAGAAGAGGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAAGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATAGTTATGAGAATTAAGGAAC
TAATGAGAGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA
ATGTCAGACGTAATAAGCGTAAGGGTTAAGAAAGAGCTGAAGAAGAGGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAAGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATAGTTATGAGAATTAAGGAAC
TAATGAGAGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | D2PIS7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3MHL6 |