Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 1000511..1001084 Replicon chromosome
Accession NZ_CP093036
Organism Bartonella krasnovii strain B51_4

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MNL10_RS04350 Protein ID WP_120122373.1
Coordinates 1000511..1000819 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MNL10_RS04355 Protein ID WP_120122374.1
Coordinates 1000800..1001084 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL10_RS04325 (MNL10_04325) 996810..996947 - 138 WP_167309298.1 hypothetical protein -
MNL10_RS04330 (MNL10_04330) 996959..997840 - 882 WP_120122370.1 hypothetical protein -
MNL10_RS04335 (MNL10_04335) 997842..998267 - 426 WP_120122371.1 hypothetical protein -
MNL10_RS04340 (MNL10_04340) 998267..999727 - 1461 WP_120122372.1 hypothetical protein -
MNL10_RS04345 (MNL10_04345) 999729..1000436 - 708 WP_120122787.1 hypothetical protein -
MNL10_RS04350 (MNL10_04350) 1000511..1000819 + 309 WP_120122373.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNL10_RS04355 (MNL10_04355) 1000800..1001084 + 285 WP_120122374.1 putative addiction module antidote protein Antitoxin
MNL10_RS04360 (MNL10_04360) 1001120..1001500 - 381 WP_120122375.1 hypothetical protein -
MNL10_RS04365 (MNL10_04365) 1001526..1002650 - 1125 WP_120122376.1 N4-gp56 family major capsid protein -
MNL10_RS04370 (MNL10_04370) 1002744..1003631 - 888 WP_241440086.1 hypothetical protein -
MNL10_RS04375 (MNL10_04375) 1003644..1004813 - 1170 Protein_853 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 981538..1043320 61782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Uncharacterized protein HI1420

(13-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11857.83 Da        Isoelectric Point: 9.7095

>T237619 WP_120122373.1 NZ_CP093036:1000511-1000819 [Bartonella krasnovii]
MILIHKTIEFDTWLKKLKDKSVKAIILQRVVRLKQGLFGDVKFFHGIGELRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

>T237619 NZ_LR882498:c1582919-1582518 [Mycobacterium tuberculosis variant microti]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGGCCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10191.69 Da        Isoelectric Point: 9.6249

>AT237619 WP_120122374.1 NZ_CP093036:1000800-1001084 [Bartonella krasnovii]
MKITPFKPEEYLKDIESQKIFLNEALKTGDAAHIADALGIVARAQNMSALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLSVQSSTS

Download         Length: 285 bp

>AT237619 NZ_LR882498:c1583173-1582916 [Mycobacterium tuberculosis variant microti]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References