Detailed information of TA system TA237618

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/ParE(toxin)
• Location: 1771212..1771687
• Replicon: chromosome
• Accession: NZ_CP093035
• Organism: Bartonella krasnovii strain B60_6

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: MNL11_RS07560
• Protein ID: WP_120121236.1
• Coordinates: 1771212..1771499 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: -
• Locus tag: MNL11_RS07565
• Protein ID: WP_241439170.1
• Coordinates: 1771499..1771687 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNL11_RS07535 (MNL11_07535)	1766821..1767339	-	519	WP_120121229.1	DUF1465 family protein	-
MNL11_RS07540 (MNL11_07540)	1767540..1768682	-	1143	WP_120121231.1	OpgC domain-containing protein	-
MNL11_RS07545 (MNL11_07545)	1768958..1769620	+	663	WP_120121233.1	thiamine phosphate synthase	-
MNL11_RS07550 (MNL11_07550)	1770223..1770624	+	402	WP_120122708.1	helix-turn-helix transcriptional regulator	-
MNL11_RS07555 (MNL11_07555)	1770631..1770852	+	222	WP_148255698.1	hypothetical protein	-
MNL11_RS07560 (MNL11_07560)	1771212..1771499	-	288	WP_120121236.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MNL11_RS07565 (MNL11_07565)	1771499..1771687	-	189	WP_241439170.1	antitoxin	Antitoxin
MNL11_RS07570 (MNL11_07570)	1772192..1772560	+	369	WP_241439171.1	helix-turn-helix transcriptional regulator	-
MNL11_RS07575 (MNL11_07575)	1772883..1773295	+	413	Protein_1469	hypothetical protein	-
MNL11_RS07580 (MNL11_07580)	1774499..1775542	+	1044	WP_120121242.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11097.98 Da
• Isoelectric Point: 10.1866

>T237618 WP_120121236.1 NZ_CP093035:c1771499-1771212 [Bartonella krasnovii]
MLPVVWLSSARDDLRQILTYIARENPSAARRMKRFLETSVLPLAEHPYLYRQSERILGLREIIAHPNYLILYRVAANQIE
IVAVVHARREFPTSL

Nucleotide

• Length: 288 bp

>T237618 NZ_LR882498:1548153-1548974 [Mycobacterium tuberculosis variant microti]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 7053.99 Da
• Isoelectric Point: 4.3167

>AT237618 WP_241439170.1 NZ_CP093035:c1771687-1771499 [Bartonella krasnovii]
MKNTLSPFISEFETVEQESSHTAWLRDKVAISLANLSPPIPHDEVMAEMDVIISQLENEQKK

Nucleotide

• Length: 189 bp

>AT237618 NZ_LR882498:1548967-1549203 [Mycobacterium tuberculosis variant microti]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG