Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 893260..893833 Replicon chromosome
Accession NZ_CP093035
Organism Bartonella krasnovii strain B60_6

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MNL11_RS03775 Protein ID WP_120122373.1
Coordinates 893525..893833 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MNL11_RS03770 Protein ID WP_120122374.1
Coordinates 893260..893544 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL11_RS03750 (MNL11_03750) 888685..890703 + 2019 WP_241436961.1 portal protein -
MNL11_RS03755 (MNL11_03755) 890716..891600 + 885 WP_120122377.1 hypothetical protein -
MNL11_RS03760 (MNL11_03760) 891694..892818 + 1125 WP_120122376.1 N4-gp56 family major capsid protein -
MNL11_RS03765 (MNL11_03765) 892844..893224 + 381 WP_120122375.1 hypothetical protein -
MNL11_RS03770 (MNL11_03770) 893260..893544 - 285 WP_120122374.1 putative addiction module antidote protein Antitoxin
MNL11_RS03775 (MNL11_03775) 893525..893833 - 309 WP_120122373.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNL11_RS03780 (MNL11_03780) 893908..894615 + 708 WP_120122787.1 hypothetical protein -
MNL11_RS03785 (MNL11_03785) 894617..896077 + 1461 WP_120122372.1 hypothetical protein -
MNL11_RS03790 (MNL11_03790) 896077..896502 + 426 WP_120122371.1 hypothetical protein -
MNL11_RS03795 (MNL11_03795) 896504..897385 + 882 WP_120122370.1 hypothetical protein -
MNL11_RS03800 (MNL11_03800) 897397..897534 + 138 WP_167309298.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 785698..912397 126699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Uncharacterized protein HI1420

(13-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11857.83 Da        Isoelectric Point: 9.7095

>T237617 WP_120122373.1 NZ_CP093035:c893833-893525 [Bartonella krasnovii]
MILIHKTIEFDTWLKKLKDKSVKAIILQRVVRLKQGLFGDVKFFHGIGELRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

>T237617 NZ_LR882498:c1392608-1392315 [Mycobacterium tuberculosis variant microti]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10191.69 Da        Isoelectric Point: 9.6249

>AT237617 WP_120122374.1 NZ_CP093035:c893544-893260 [Bartonella krasnovii]
MKITPFKPEEYLKDIESQKIFLNEALKTGDAAHIADALGIVARAQNMSALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLSVQSSTS

Download         Length: 285 bp

>AT237617 NZ_LR882498:c1392874-1392605 [Mycobacterium tuberculosis variant microti]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGTCACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References