Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 832067..832640 Replicon chromosome
Accession NZ_CP093035
Organism Bartonella krasnovii strain B60_6

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MNL11_RS03470 Protein ID WP_120122373.1
Coordinates 832332..832640 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MNL11_RS03465 Protein ID WP_120122374.1
Coordinates 832067..832351 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL11_RS03445 (MNL11_03445) 828341..829510 + 1170 Protein_672 phage portal protein -
MNL11_RS03450 (MNL11_03450) 829523..830407 + 885 WP_241441018.1 hypothetical protein -
MNL11_RS03455 (MNL11_03455) 830501..831625 + 1125 WP_120122376.1 N4-gp56 family major capsid protein -
MNL11_RS03460 (MNL11_03460) 831651..832031 + 381 WP_120122375.1 hypothetical protein -
MNL11_RS03465 (MNL11_03465) 832067..832351 - 285 WP_120122374.1 putative addiction module antidote protein Antitoxin
MNL11_RS03470 (MNL11_03470) 832332..832640 - 309 WP_120122373.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNL11_RS03475 (MNL11_03475) 832715..833422 + 708 WP_120122787.1 hypothetical protein -
MNL11_RS03480 (MNL11_03480) 833424..834884 + 1461 WP_120122372.1 hypothetical protein -
MNL11_RS03485 (MNL11_03485) 834884..835309 + 426 WP_120122371.1 hypothetical protein -
MNL11_RS03490 (MNL11_03490) 835311..836150 + 840 WP_241441019.1 hypothetical protein -
MNL11_RS03495 (MNL11_03495) 836158..837630 + 1473 WP_241441020.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 785698..912397 126699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Uncharacterized protein HI1420

(13-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11857.83 Da        Isoelectric Point: 9.7095

>T237616 WP_120122373.1 NZ_CP093035:c832640-832332 [Bartonella krasnovii]
MILIHKTIEFDTWLKKLKDKSVKAIILQRVVRLKQGLFGDVKFFHGIGELRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

>T237616 NZ_LR882498:1388165-1388596 [Mycobacterium tuberculosis variant microti]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10191.69 Da        Isoelectric Point: 9.6249

>AT237616 WP_120122374.1 NZ_CP093035:c832351-832067 [Bartonella krasnovii]
MKITPFKPEEYLKDIESQKIFLNEALKTGDAAHIADALGIVARAQNMSALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLSVQSSTS

Download         Length: 285 bp

>AT237616 NZ_LR882498:1387908-1388168 [Mycobacterium tuberculosis variant microti]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References