Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 714149..714738 Replicon chromosome
Accession NZ_CP093035
Organism Bartonella krasnovii strain B60_6

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MNL11_RS02895 Protein ID WP_120122258.1
Coordinates 714406..714738 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MNL11_RS02890 Protein ID WP_120122257.1
Coordinates 714149..714406 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL11_RS02865 (MNL11_02865) 710110..710310 - 201 WP_007347430.1 DNA-binding protein -
MNL11_RS02870 (MNL11_02870) 710520..711686 - 1167 WP_241441009.1 site-specific integrase -
MNL11_RS02875 (MNL11_02875) 711923..712786 + 864 WP_120122254.1 hypothetical protein -
MNL11_RS02880 (MNL11_02880) 713062..713505 + 444 WP_120122255.1 single-stranded DNA-binding protein -
MNL11_RS02885 (MNL11_02885) 713560..714054 + 495 WP_120122256.1 hypothetical protein -
MNL11_RS02890 (MNL11_02890) 714149..714406 + 258 WP_120122257.1 antitoxin Antitoxin
MNL11_RS02895 (MNL11_02895) 714406..714738 + 333 WP_120122258.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNL11_RS02900 (MNL11_02900) 714926..715636 - 711 WP_120122259.1 hypothetical protein -
MNL11_RS02905 (MNL11_02905) 715944..716279 + 336 WP_120122260.1 hypothetical protein -
MNL11_RS02910 (MNL11_02910) 716260..717585 + 1326 WP_120122261.1 phage terminase large subunit -
MNL11_RS02915 (MNL11_02915) 717570..719618 + 2049 WP_120122262.1 portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 670788..748538 77750


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11853.95 Da        Isoelectric Point: 10.5590

>T237615 WP_120122258.1 NZ_CP093035:714406-714738 [Bartonella krasnovii]
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIGARQGKKMETVPPMIMNEVLAKLATFLT

Download         Length: 333 bp

>T237615 NZ_LR882498:1243224-1243598 [Mycobacterium tuberculosis variant microti]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9346.69 Da        Isoelectric Point: 3.8857

>AT237615 WP_120122257.1 NZ_CP093035:714149-714406 [Bartonella krasnovii]
MYTTKLRKVGGSVMLSIPPVLLDVLHLTENTQVGLAVDNGQLIVKPQTFPSYTLDELLAQCNPSVDFADEDIEWFDAQPV
GSELL

Download         Length: 258 bp

>AT237615 NZ_LR882498:1243030-1243227 [Mycobacterium tuberculosis variant microti]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References