Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/ParE(toxin)
Location 1668896..1669371 Replicon chromosome
Accession NZ_CP093034
Organism Bartonella krasnovii strain B71_4

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag MNL12_RS06880 Protein ID WP_120121236.1
Coordinates 1668896..1669183 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag MNL12_RS06885 Protein ID WP_241439170.1
Coordinates 1669183..1669371 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL12_RS06855 (MNL12_06855) 1664505..1665023 - 519 WP_120121229.1 DUF1465 family protein -
MNL12_RS06860 (MNL12_06860) 1665224..1666366 - 1143 WP_120121231.1 OpgC domain-containing protein -
MNL12_RS06865 (MNL12_06865) 1666642..1667304 + 663 WP_120121233.1 thiamine phosphate synthase -
MNL12_RS06870 (MNL12_06870) 1667940..1668308 + 369 WP_241439167.1 helix-turn-helix transcriptional regulator -
MNL12_RS06875 (MNL12_06875) 1668315..1668536 + 222 WP_241439168.1 hypothetical protein -
MNL12_RS06880 (MNL12_06880) 1668896..1669183 - 288 WP_120121236.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNL12_RS06885 (MNL12_06885) 1669183..1669371 - 189 WP_241439170.1 antitoxin Antitoxin
MNL12_RS06890 (MNL12_06890) 1669876..1670244 + 369 WP_241439171.1 helix-turn-helix transcriptional regulator -
MNL12_RS06895 (MNL12_06895) 1670567..1670979 + 413 Protein_1334 hypothetical protein -
MNL12_RS06900 (MNL12_06900) 1672183..1673226 + 1044 WP_120121242.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11097.98 Da        Isoelectric Point: 10.1866

>T237614 WP_120121236.1 NZ_CP093034:c1669183-1668896 [Bartonella krasnovii]
MLPVVWLSSARDDLRQILTYIARENPSAARRMKRFLETSVLPLAEHPYLYRQSERILGLREIIAHPNYLILYRVAANQIE
IVAVVHARREFPTSL

Download         Length: 288 bp

>T237614 NZ_LR882498:c1234585-1234274 [Mycobacterium tuberculosis variant microti]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7053.99 Da        Isoelectric Point: 4.3167

>AT237614 WP_241439170.1 NZ_CP093034:c1669371-1669183 [Bartonella krasnovii]
MKNTLSPFISEFETVEQESSHTAWLRDKVAISLANLSPPIPHDEVMAEMDVIISQLENEQKK

Download         Length: 189 bp

>AT237614 NZ_LR882498:c1234905-1234585 [Mycobacterium tuberculosis variant microti]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References