Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/ParE(toxin)
Location 1671630..1672105 Replicon chromosome
Accession NZ_CP093033
Organism Bartonella krasnovii strain B35_1_2

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag MNL13_RS06920 Protein ID WP_120121236.1
Coordinates 1671630..1671917 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag MNL13_RS06925 Protein ID WP_241439170.1
Coordinates 1671917..1672105 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL13_RS06895 (MNL13_06895) 1667239..1667757 - 519 WP_120121229.1 DUF1465 family protein -
MNL13_RS06900 (MNL13_06900) 1667958..1669100 - 1143 WP_120121231.1 OpgC domain-containing protein -
MNL13_RS06905 (MNL13_06905) 1669376..1670038 + 663 WP_241448556.1 thiamine phosphate synthase -
MNL13_RS06910 (MNL13_06910) 1670641..1671042 + 402 WP_120122708.1 helix-turn-helix transcriptional regulator -
MNL13_RS06915 (MNL13_06915) 1671049..1671270 + 222 WP_148255698.1 hypothetical protein -
MNL13_RS06920 (MNL13_06920) 1671630..1671917 - 288 WP_120121236.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNL13_RS06925 (MNL13_06925) 1671917..1672105 - 189 WP_241439170.1 antitoxin Antitoxin
MNL13_RS06930 (MNL13_06930) 1672610..1672978 + 369 WP_241448557.1 helix-turn-helix transcriptional regulator -
MNL13_RS06935 (MNL13_06935) 1673301..1673713 + 413 Protein_1343 hypothetical protein -
MNL13_RS06940 (MNL13_06940) 1674917..1675960 + 1044 WP_120121242.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11097.98 Da        Isoelectric Point: 10.1866

>T237612 WP_120121236.1 NZ_CP093033:c1671917-1671630 [Bartonella krasnovii]
MLPVVWLSSARDDLRQILTYIARENPSAARRMKRFLETSVLPLAEHPYLYRQSERILGLREIIAHPNYLILYRVAANQIE
IVAVVHARREFPTSL

Download         Length: 288 bp

>T237612 NZ_LR882498:1016339-1016773 [Mycobacterium tuberculosis variant microti]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7053.99 Da        Isoelectric Point: 4.3167

>AT237612 WP_241439170.1 NZ_CP093033:c1672105-1671917 [Bartonella krasnovii]
MKNTLSPFISEFETVEQESSHTAWLRDKVAISLANLSPPIPHDEVMAEMDVIISQLENEQKK

Download         Length: 189 bp

>AT237612 NZ_LR882498:1016154-1016333 [Mycobacterium tuberculosis variant microti]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCAGGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References