Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 794405..794978 Replicon chromosome
Accession NZ_CP093033
Organism Bartonella krasnovii strain B35_1_2

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MNL13_RS03250 Protein ID WP_120122373.1
Coordinates 794670..794978 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MNL13_RS03245 Protein ID WP_120122374.1
Coordinates 794405..794689 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL13_RS03225 (MNL13_03225) 789830..791848 + 2019 WP_241436961.1 portal protein -
MNL13_RS03230 (MNL13_03230) 791861..792745 + 885 WP_120122377.1 hypothetical protein -
MNL13_RS03235 (MNL13_03235) 792839..793963 + 1125 WP_120122376.1 N4-gp56 family major capsid protein -
MNL13_RS03240 (MNL13_03240) 793989..794369 + 381 WP_120122375.1 hypothetical protein -
MNL13_RS03245 (MNL13_03245) 794405..794689 - 285 WP_120122374.1 putative addiction module antidote protein Antitoxin
MNL13_RS03250 (MNL13_03250) 794670..794978 - 309 WP_120122373.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNL13_RS03255 (MNL13_03255) 795053..795760 + 708 WP_120122787.1 hypothetical protein -
MNL13_RS03260 (MNL13_03260) 795762..797222 + 1461 WP_120122372.1 hypothetical protein -
MNL13_RS03265 (MNL13_03265) 797222..797647 + 426 WP_120122371.1 hypothetical protein -
MNL13_RS03270 (MNL13_03270) 797649..798530 + 882 WP_120122370.1 hypothetical protein -
MNL13_RS03275 (MNL13_03275) 798542..798679 + 138 WP_167309298.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 756910..813658 56748


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Uncharacterized protein HI1420

(13-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11857.83 Da        Isoelectric Point: 9.7095

>T237611 WP_120122373.1 NZ_CP093033:c794978-794670 [Bartonella krasnovii]
MILIHKTIEFDTWLKKLKDKSVKAIILQRVVRLKQGLFGDVKFFHGIGELRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

>T237611 NZ_LR882498:843904-844332 [Mycobacterium tuberculosis variant microti]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10191.69 Da        Isoelectric Point: 9.6249

>AT237611 WP_120122374.1 NZ_CP093033:c794689-794405 [Bartonella krasnovii]
MKITPFKPEEYLKDIESQKIFLNEALKTGDAAHIADALGIVARAQNMSALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLSVQSSTS

Download         Length: 285 bp

>AT237611 NZ_LR882498:843623-843880 [Mycobacterium tuberculosis variant microti]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References