Detailed information of TA system TA023761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 679650..680215
• Replicon: chromosome
• Accession: NC_012622
• Organism: Sulfolobus islandicus Y.G.57.14

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: C3NC10
• Locus tag: YG5714_RS03550
• Protein ID: WP_012715821.1
• Coordinates: 679650..679958 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: YG5714_RS03555
• Protein ID: WP_187146859.1
• Coordinates: 679955..680215 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YG5714_RS03525 (YG5714_0721)	675186..675602	+	417	WP_012713163.1	hypothetical protein	-
YG5714_RS16175	675707..675847	+	141	Protein_738	ISNCY family transposase	-
YG5714_RS03530 (YG5714_0723)	675997..676770	-	774	WP_009991748.1	extradiol dioxygenase	-
YG5714_RS03535 (YG5714_0724)	677031..677450	-	420	WP_012715818.1	DUF4143 domain-containing protein	-
YG5714_RS15845 (YG5714_0725)	678398..678562	+	165	WP_012715820.1	hypothetical protein	-
YG5714_RS03545 (YG5714_0726)	678552..679634	+	1083	Protein_742	hypothetical protein	-
YG5714_RS03550 (YG5714_0728)	679650..679958	-	309	WP_012715821.1	type II toxin-antitoxin system VapC family toxin	Toxin
YG5714_RS03555 (YG5714_0729)	679955..680215	-	261	WP_187146859.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
YG5714_RS03560 (YG5714_0730)	680592..680828	+	237	WP_009991916.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
YG5714_RS03565 (YG5714_0731)	680806..681204	+	399	WP_012715823.1	type II toxin-antitoxin system VapC family toxin	-
YG5714_RS03570 (YG5714_0732)	681472..682203	-	732	WP_012715824.1	IS1 family transposase	-
YG5714_RS03575 (YG5714_0733)	682394..682618	+	225	WP_009991920.1	type II toxin-antitoxin system CcdA family antitoxin	-
YG5714_RS03580 (YG5714_0734)	682608..683000	+	393	WP_012715825.1	type II toxin-antitoxin system VapC family toxin	-
YG5714_RS03585 (YG5714_0735)	683174..684118	+	945	WP_012715826.1	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-97)

Antitoxin

• SpoVT-AbrB domain (4-46)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 12041.07 Da
• Isoelectric Point: 4.8779

>T23761 WP_012715821.1 NC_012622:c679958-679650 [Sulfolobus islandicus Y.G.57.14]
MIFLDANFLIYLNSGVSEVKEYYIKLLTYESLFSDPLVIDEVIYVSKKKYGVKYCDTIEFLDEIVLKYLTVLPITIKEYE
RAKEIMRKYSVKPSDAIDNSFR

Nucleotide

• Length: 309 bp

>T23761 NC_012622:c679958-679650 [Sulfolobus islandicus Y.G.57.14]
TTGATTTTTCTTGATGCTAATTTCTTAATCTACTTAAACTCGGGTGTAAGTGAGGTAAAAGAGTATTATATAAAACTCCT
CACATATGAAAGCTTGTTTTCAGATCCTTTAGTTATAGATGAGGTAATATACGTGTCTAAGAAGAAGTATGGAGTTAAGT
ATTGCGATACCATAGAATTCTTGGATGAAATAGTGCTCAAGTACTTAACAGTTTTACCAATCACGATAAAGGAATATGAG
AGGGCTAAAGAAATTATGAGAAAATACTCAGTTAAGCCATCTGATGCCATTGACAACAGTTTCCGATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9859.53 Da
• Isoelectric Point: 5.2739

>AT23761 WP_187146859.1 NC_012622:c680215-679955 [Sulfolobus islandicus Y.G.57.14]
MTLRVEVGKKGYIIIPKSVRDLVGIKEGDILILTVVGDKIILEPERKVNIREVVKKLEEHERKISYAKRASLGELENISL
EEEFED

Nucleotide

• Length: 261 bp

>AT23761 NC_012622:c680215-679955 [Sulfolobus islandicus Y.G.57.14]
TTGACTCTAAGAGTGGAAGTTGGAAAGAAGGGTTATATAATAATTCCTAAAAGTGTAAGGGATTTGGTGGGAATAAAAGA
GGGGGATATCTTAATTTTGACAGTCGTTGGAGATAAGATAATCTTAGAACCTGAGAGGAAGGTTAACATACGAGAAGTTG
TCAAAAAATTAGAAGAACATGAGAGGAAGATATCTTATGCTAAAAGGGCAAGCCTTGGGGAACTTGAGAACATAAGTCTT
GAAGAGGAATTTGAAGATTGA

Structures

Toxin

• AlphaFold DB: C3NC10