Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4989628..4990886 Replicon chromosome
Accession NZ_CP093032
Organism Pseudomonas aeruginosa strain H02

Toxin (Protein)


Gene name - Uniprot ID A0A0H2Z7F3
Locus tag MMZ65_RS23375 Protein ID WP_003140635.1
Coordinates 4989628..4990383 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag MMZ65_RS23380 Protein ID WP_003086329.1
Coordinates 4990518..4990886 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ65_RS23365 (MMZ65_23365) 4984799..4987342 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
MMZ65_RS23370 (MMZ65_23370) 4987497..4988858 - 1362 WP_003081943.1 DNA recombination protein RmuC -
MMZ65_RS23375 (MMZ65_23375) 4989628..4990383 - 756 WP_003140635.1 RES family NAD+ phosphorylase Toxin
MMZ65_RS23380 (MMZ65_23380) 4990518..4990886 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
MMZ65_RS23385 (MMZ65_23385) 4990959..4992245 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
MMZ65_RS23390 (MMZ65_23390) 4992301..4993890 - 1590 WP_003140637.1 aldehyde dehydrogenase family protein -
MMZ65_RS23395 (MMZ65_23395) 4993969..4994445 + 477 WP_003140638.1 hypothetical protein -
MMZ65_RS23400 (MMZ65_23400) 4994448..4994723 - 276 WP_023098713.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28220.34 Da        Isoelectric Point: 7.7294

>T237609 WP_003140635.1 NZ_CP093032:c4990383-4989628 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

>T237609 NZ_LR882498:c757788-757351 [Mycobacterium tuberculosis variant microti]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT237609 WP_003086329.1 NZ_CP093032:c4990886-4990518 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT237609 NZ_LR882498:c757241-756996 [Mycobacterium tuberculosis variant microti]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z7F3

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References