Detailed information of TA system TA237608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3940529..3941749
• Replicon: chromosome
• Accession: NZ_CP093032
• Organism: Pseudomonas aeruginosa strain H02

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0H2Z8V4
• Locus tag: MMZ65_RS18465
• Protein ID: WP_003110488.1
• Coordinates: 3941171..3941749 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MMZ65_RS18460
• Protein ID: WP_003088112.1
• Coordinates: 3940529..3941083 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ65_RS18435 (MMZ65_18435)	3936097..3936648	+	552	WP_003139878.1	XRE family transcriptional regulator	-
MMZ65_RS18440 (MMZ65_18440)	3936645..3937043	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
MMZ65_RS18445 (MMZ65_18445)	3937056..3937379	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
MMZ65_RS18450 (MMZ65_18450)	3937710..3938171	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
MMZ65_RS18455 (MMZ65_18455)	3938176..3940371	+	2196	WP_003139882.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
MMZ65_RS18460 (MMZ65_18460)	3940529..3941083	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
MMZ65_RS18465 (MMZ65_18465)	3941171..3941749	+	579	WP_003110488.1	HD domain-containing protein	Toxin
MMZ65_RS18470 (MMZ65_18470)	3941858..3943045	-	1188	WP_003139884.1	HlyD family efflux transporter periplasmic adaptor subunit	-
MMZ65_RS18475 (MMZ65_18475)	3943035..3945206	-	2172	WP_003139887.1	type I secretion system permease/ATPase	-
MMZ65_RS18480 (MMZ65_18480)	3945196..3946473	-	1278	WP_003139889.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21913.75 Da
• Isoelectric Point: 5.3655

>T237608 WP_003110488.1 NZ_CP093032:3941171-3941749 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T237608 NZ_LR882498:c757009-756701 [Mycobacterium tuberculosis variant microti]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT237608 WP_003088112.1 NZ_CP093032:3940529-3941083 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT237608 NZ_LR882498:c757241-756996 [Mycobacterium tuberculosis variant microti]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Structures

Toxin

• AlphaFold DB: A0A0H2Z8V4