Detailed information of TA system TA237606

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 278118..279073
• Replicon: chromosome
• Accession: NZ_CP093032
• Organism: Pseudomonas aeruginosa strain H02

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MMZ65_RS01285
• Protein ID: WP_170868735.1
• Coordinates: 278747..279073 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: MMZ65_RS01280
• Protein ID: WP_023107584.1
• Coordinates: 278118..278675 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ65_RS01255 (MMZ65_01255)	273175..273462	-	288	WP_241496136.1	hypothetical protein	-
MMZ65_RS01260 (MMZ65_01260)	273554..274030	-	477	WP_003118626.1	MarR family transcriptional regulator	-
MMZ65_RS01265 (MMZ65_01265)	274071..275561	-	1491	WP_003137133.1	UbiD family decarboxylase HudA	-
MMZ65_RS01270 (MMZ65_01270)	275695..276381	-	687	WP_003106170.1	YoaK family protein	-
MMZ65_RS01275 (MMZ65_01275)	276545..277477	-	933	WP_003084116.1	hypothetical protein	-
MMZ65_RS01280 (MMZ65_01280)	278118..278675	+	558	WP_023107584.1	Panacea domain-containing protein	Antitoxin
MMZ65_RS01285 (MMZ65_01285)	278747..279073	+	327	WP_170868735.1	hypothetical protein	Toxin
MMZ65_RS01295 (MMZ65_01295)	280515..281957	-	1443	WP_003133043.1	DUF2875 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (28-138)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12385.38 Da
• Isoelectric Point: 9.1081

>T237606 WP_170868735.1 NZ_CP093032:278747-279073 [Pseudomonas aeruginosa]
MNDPVYCPVLGYDAVLLVNISTVYPDKYFDQSCILKKGCHPFVLRDSWVVYREAGPFNLARLEQGVAQKSIKTHQPINAG
DFTRIRAGFDISPDVKIKVERFMRQHKI

Nucleotide

• Length: 327 bp

>T237606 NZ_LR882498:719765-720172 [Mycobacterium tuberculosis variant microti]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 21377.14 Da
• Isoelectric Point: 5.8950

>AT237606 WP_023107584.1 NZ_CP093032:278118-278675 [Pseudomonas aeruginosa]
VIFSEQKVAHMAAFFLASAEGPLPHLTLIKLLYLADRESMARFDVPMSDDRAVSMPHGPVLSSTLDLIKGRLRSEVWSAW
ISPLVDHEVRLVHDVENWDDLDELSRSDRSILESVWQEFGHMTKYQLRDYTHHHIGEWHDPHGSSRDIDPKDTFMALGQS
EELAEIKARDLAERRRHGRKLSEFI

Nucleotide

• Length: 558 bp

>AT237606 NZ_LR882498:719508-719768 [Mycobacterium tuberculosis variant microti]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA