Detailed information of TA system TA237605

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 141024..141529
• Replicon: chromosome
• Accession: NZ_CP093032
• Organism: Pseudomonas aeruginosa strain H02

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: MMZ65_RS00645
• Protein ID: WP_003083773.1
• Coordinates: 141024..141305 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0H2ZJU8
• Locus tag: MMZ65_RS00650
• Protein ID: WP_003137009.1
• Coordinates: 141302..141529 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ65_RS00620 (MMZ65_00620)	136275..137624	+	1350	WP_003137006.1	C4-dicarboxylate transporter DctA	-
MMZ65_RS00625 (MMZ65_00625)	137673..138359	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MMZ65_RS00630 (MMZ65_00630)	138460..139194	+	735	WP_003110658.1	GntR family transcriptional regulator	-
MMZ65_RS00635 (MMZ65_00635)	139374..139784	+	411	WP_003110659.1	aegerolysin family protein	-
MMZ65_RS00640 (MMZ65_00640)	139816..140724	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MMZ65_RS00645 (MMZ65_00645)	141024..141305	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
MMZ65_RS00650 (MMZ65_00650)	141302..141529	-	228	WP_003137009.1	CopG family ribbon-helix-helix protein	Antitoxin
MMZ65_RS00655 (MMZ65_00655)	141705..142328	-	624	WP_003137011.1	hypothetical protein	-
MMZ65_RS00660 (MMZ65_00660)	142429..142929	+	501	WP_003137013.1	LEA type 2 family protein	-
MMZ65_RS00665 (MMZ65_00665)	143001..143342	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MMZ65_RS00670 (MMZ65_00670)	143424..144851	-	1428	WP_003137015.1	GABA permease	-
MMZ65_RS00675 (MMZ65_00675)	145020..146513	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T237605 WP_003083773.1 NZ_CP093032:c141305-141024 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T237605 NZ_LR882498:718147-718542 [Mycobacterium tuberculosis variant microti]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8526.56 Da
• Isoelectric Point: 5.5740

>AT237605 WP_003137009.1 NZ_CP093032:c141529-141302 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT237605 NZ_LR882498:717893-718147 [Mycobacterium tuberculosis variant microti]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A0H2ZJU8