Detailed information of TA system TA237603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4813010..4814268
• Replicon: chromosome
• Accession: NZ_CP093031
• Organism: Pseudomonas aeruginosa strain H03

Toxin (Protein)

• Gene name: -
• Uniprot ID: V6AJ34
• Locus tag: MMZ66_RS22535
• Protein ID: WP_003086331.1
• Coordinates: 4813010..4813765 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: MMZ66_RS22540
• Protein ID: WP_003086329.1
• Coordinates: 4813900..4814268 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ66_RS22525 (MMZ66_22535)	4808181..4810724	+	2544	WP_003134033.1	acyl-homoserine-lactone acylase QuiP	-
MMZ66_RS22530 (MMZ66_22540)	4810879..4812240	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
MMZ66_RS22535 (MMZ66_22545)	4813010..4813765	-	756	WP_003086331.1	RES family NAD+ phosphorylase	Toxin
MMZ66_RS22540 (MMZ66_22550)	4813900..4814268	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
MMZ66_RS22545 (MMZ66_22555)	4814341..4815627	-	1287	WP_003086327.1	FAD-binding oxidoreductase	-
MMZ66_RS22550 (MMZ66_22560)	4815683..4817272	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
MMZ66_RS22555 (MMZ66_22565)	4817351..4817827	+	477	WP_003086322.1	hypothetical protein	-
MMZ66_RS22560 (MMZ66_22570)	4817830..4818105	-	276	WP_023098713.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28236.34 Da
• Isoelectric Point: 7.7294

>T237603 WP_003086331.1 NZ_CP093031:c4813765-4813010 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T237603 NZ_LR882498:704959-705360 [Mycobacterium tuberculosis variant microti]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT237603 WP_003086329.1 NZ_CP093031:c4814268-4813900 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT237603 NZ_LR882498:704717-704962 [Mycobacterium tuberculosis variant microti]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Structures

Toxin

• AlphaFold DB: V6AJ34

Antitoxin

• AlphaFold DB: V6AJU7