Detailed information of TA system TA237602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3876268..3877489
• Replicon: chromosome
• Accession: NZ_CP093031
• Organism: Pseudomonas aeruginosa strain H03

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: V6AG16
• Locus tag: MMZ66_RS18135
• Protein ID: WP_003088107.1
• Coordinates: 3876911..3877489 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MMZ66_RS18130
• Protein ID: WP_003088112.1
• Coordinates: 3876268..3876822 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ66_RS18105 (MMZ66_18115)	3871836..3872387	+	552	WP_023098678.1	XRE family transcriptional regulator	-
MMZ66_RS18110 (MMZ66_18120)	3872384..3872782	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
MMZ66_RS18115 (MMZ66_18125)	3872795..3873118	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
MMZ66_RS18120 (MMZ66_18130)	3873449..3873910	+	462	WP_003088117.1	(2Fe-2S)-binding protein	-
MMZ66_RS18125 (MMZ66_18135)	3873915..3876110	+	2196	WP_003088114.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
MMZ66_RS18130 (MMZ66_18140)	3876268..3876822	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
MMZ66_RS18135 (MMZ66_18145)	3876911..3877489	+	579	WP_003088107.1	HD domain-containing protein	Toxin
MMZ66_RS18140 (MMZ66_18150)	3877598..3878785	-	1188	WP_003088106.1	HlyD family efflux transporter periplasmic adaptor subunit	-
MMZ66_RS18145 (MMZ66_18155)	3878775..3880946	-	2172	WP_003088105.1	type I secretion system permease/ATPase	-
MMZ66_RS18150 (MMZ66_18160)	3880936..3882213	-	1278	WP_003088104.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-187)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21885.74 Da
• Isoelectric Point: 5.3655

>T237602 WP_003088107.1 NZ_CP093031:3876911-3877489 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T237602 NZ_LR882498:c699040-698627 [Mycobacterium tuberculosis variant microti]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT237602 WP_003088112.1 NZ_CP093031:3876268-3876822 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT237602 NZ_LR882498:c699273-699037 [Mycobacterium tuberculosis variant microti]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Structures

Toxin

• AlphaFold DB: V6AG16