Detailed information of TA system TA237598

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 147370..147875
• Replicon: chromosome
• Accession: NZ_CP093031
• Organism: Pseudomonas aeruginosa strain H03

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: MMZ66_RS00660
• Protein ID: WP_003083773.1
• Coordinates: 147370..147651 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: MMZ66_RS00665
• Protein ID: WP_003083775.1
• Coordinates: 147648..147875 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ66_RS00635 (MMZ66_00635)	142621..143970	+	1350	WP_003137006.1	C4-dicarboxylate transporter DctA	-
MMZ66_RS00640 (MMZ66_00640)	144019..144705	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MMZ66_RS00645 (MMZ66_00645)	144806..145540	+	735	WP_003083764.1	GntR family transcriptional regulator	-
MMZ66_RS00650 (MMZ66_00650)	145720..146130	+	411	WP_003110659.1	aegerolysin family protein	-
MMZ66_RS00655 (MMZ66_00655)	146162..147070	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MMZ66_RS00660 (MMZ66_00660)	147370..147651	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
MMZ66_RS00665 (MMZ66_00665)	147648..147875	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
MMZ66_RS00670 (MMZ66_00670)	148051..148671	-	621	WP_003101226.1	hypothetical protein	-
MMZ66_RS00675 (MMZ66_00675)	148772..149272	+	501	WP_003083778.1	LEA type 2 family protein	-
MMZ66_RS00680 (MMZ66_00680)	149345..149686	+	342	WP_014603467.1	zinc ribbon domain-containing protein YjdM	-
MMZ66_RS00685 (MMZ66_00685)	149768..151195	-	1428	WP_003083784.1	GABA permease	-
MMZ66_RS00690 (MMZ66_00690)	151364..152857	-	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T237598 WP_003083773.1 NZ_CP093031:c147651-147370 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T237598 NZ_LR882498:365276-365701 [Mycobacterium tuberculosis variant microti]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT237598 WP_003083775.1 NZ_CP093031:c147875-147648 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT237598 NZ_LR882498:365058-365279 [Mycobacterium tuberculosis variant microti]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9