Detailed information of TA system TA237594

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3839635..3840856
• Replicon: chromosome
• Accession: NZ_CP093030
• Organism: Pseudomonas aeruginosa strain H04

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: MMZ67_RS18005
• Protein ID: WP_003102740.1
• Coordinates: 3840278..3840856 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MMZ67_RS18000
• Protein ID: WP_003088112.1
• Coordinates: 3839635..3840189 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ67_RS17975 (MMZ67_17985)	3835203..3835754	+	552	WP_003450159.1	XRE family transcriptional regulator	-
MMZ67_RS17980 (MMZ67_17990)	3835751..3836149	-	399	WP_023082958.1	NADH-quinone oxidoreductase subunit A	-
MMZ67_RS17985 (MMZ67_17995)	3836162..3836485	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
MMZ67_RS17990 (MMZ67_18000)	3836816..3837277	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
MMZ67_RS17995 (MMZ67_18005)	3837282..3839477	+	2196	WP_023464651.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
MMZ67_RS18000 (MMZ67_18010)	3839635..3840189	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
MMZ67_RS18005 (MMZ67_18015)	3840278..3840856	+	579	WP_003102740.1	HD domain-containing protein	Toxin
MMZ67_RS18010 (MMZ67_18020)	3840965..3842152	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
MMZ67_RS18015 (MMZ67_18025)	3842142..3844313	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
MMZ67_RS18020 (MMZ67_18030)	3844303..3845580	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T237594 WP_003102740.1 NZ_CP093030:3840278-3840856 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T237594 NZ_LR882497:3817658-3818068 [Mycobacterium tuberculosis variant microti]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT237594 WP_003088112.1 NZ_CP093030:3839635-3840189 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT237594 NZ_LR882497:3817383-3817661 [Mycobacterium tuberculosis variant microti]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07