Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | chpB-mazE/PRK09812-ChpS |
| Location | 59977..60572 | Replicon | plasmid unnamed |
| Accession | NZ_CP093029 | ||
| Organism | Pseudomonas aeruginosa strain H05 | ||
Toxin (Protein)
| Gene name | chpB | Uniprot ID | A0A2K4Y2Z0 |
| Locus tag | MMZ68_RS33575 | Protein ID | WP_023100676.1 |
| Coordinates | 59977..60327 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | MMZ68_RS33580 | Protein ID | WP_034017785.1 |
| Coordinates | 60324..60572 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MMZ68_RS33540 (MMZ68_33540) | 55679..56170 | + | 492 | WP_128549492.1 | hypothetical protein | - |
| MMZ68_RS33545 (MMZ68_33545) | 56402..57145 | + | 744 | WP_023100671.1 | glyoxalase superfamily protein | - |
| MMZ68_RS33550 (MMZ68_33550) | 57469..57732 | + | 264 | WP_020303033.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| MMZ68_RS33555 (MMZ68_33555) | 57719..58000 | + | 282 | WP_023100672.1 | type II toxin-antitoxin system YafQ family toxin | - |
| MMZ68_RS33560 (MMZ68_33560) | 58037..58372 | + | 336 | WP_023100673.1 | hypothetical protein | - |
| MMZ68_RS33565 (MMZ68_33565) | 58754..59206 | + | 453 | WP_023100674.1 | hypothetical protein | - |
| MMZ68_RS33570 (MMZ68_33570) | 59255..59977 | - | 723 | WP_031634065.1 | hypothetical protein | - |
| MMZ68_RS33575 (MMZ68_33575) | 59977..60327 | - | 351 | WP_023100676.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MMZ68_RS33580 (MMZ68_33580) | 60324..60572 | - | 249 | WP_034017785.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| MMZ68_RS33585 (MMZ68_33585) | 60569..60988 | - | 420 | WP_057380713.1 | hypothetical protein | - |
| MMZ68_RS33590 (MMZ68_33590) | 61062..61538 | - | 477 | WP_034026837.1 | single-stranded DNA-binding protein | - |
| MMZ68_RS33595 (MMZ68_33595) | 61589..61987 | - | 399 | WP_176742248.1 | hypothetical protein | - |
| MMZ68_RS33600 (MMZ68_33600) | 61996..62679 | - | 684 | WP_034018055.1 | hypothetical protein | - |
| MMZ68_RS33605 (MMZ68_33605) | 62676..63212 | - | 537 | WP_034018056.1 | hypothetical protein | - |
| MMZ68_RS33610 (MMZ68_33610) | 63209..63439 | - | 231 | WP_034018057.1 | hypothetical protein | - |
| MMZ68_RS33615 (MMZ68_33615) | 63429..65504 | - | 2076 | WP_128549493.1 | DNA cytosine methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..143021 | 143021 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12073.06 Da Isoelectric Point: 10.1005
>T237590 WP_023100676.1 NZ_CP093029:c60327-59977 [Pseudomonas aeruginosa]
MSKRLQHQFDRGDIVSLDMGSASAQAACKALVLSPAAYNVLGLALAIPITEHDSSRYAGFAVAILLPGRTPAKGAALVNL
VRPVDLAARGAKLLGKAPQTTIDEALQRLQAVVGKD
MSKRLQHQFDRGDIVSLDMGSASAQAACKALVLSPAAYNVLGLALAIPITEHDSSRYAGFAVAILLPGRTPAKGAALVNL
VRPVDLAARGAKLLGKAPQTTIDEALQRLQAVVGKD
Download Length: 351 bp
>T237590 NZ_LR882497:3555256-3555600 [Mycobacterium tuberculosis variant microti]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8753.01 Da Isoelectric Point: 4.1093
>AT237590 WP_034017785.1 NZ_CP093029:c60572-60324 [Pseudomonas aeruginosa]
MKTTIRAIGNSQGITIPKPLLAELGVSLGDPVDISFKDQTLVVTKVATEYDLSTLVAQCDLEAPEPPDIQCWRTATPVGN
EA
MKTTIRAIGNSQGITIPKPLLAELGVSLGDPVDISFKDQTLVVTKVATEYDLSTLVAQCDLEAPEPPDIQCWRTATPVGN
EA
Download Length: 249 bp
>AT237590 NZ_LR882497:3555597-3555926 [Mycobacterium tuberculosis variant microti]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|