Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 343383..343900 Replicon chromosome
Accession NC_012590
Organism Corynebacterium aurimucosum ATCC 700975

Toxin (Protein)


Gene name relE Uniprot ID C3PKG9
Locus tag CAURI_RS01695 Protein ID WP_010189797.1
Coordinates 343383..343637 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C3PKH0
Locus tag CAURI_RS01700 Protein ID WP_010189796.1
Coordinates 343643..343900 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAURI_RS01670 338531..339508 + 978 WP_010189806.1 porphobilinogen synthase -
CAURI_RS01675 339519..340232 + 714 WP_010189804.1 hypothetical protein -
CAURI_RS01680 340229..340726 + 498 WP_010189802.1 hypothetical protein -
CAURI_RS01685 340765..341805 + 1041 WP_010189800.1 uroporphyrinogen decarboxylase -
CAURI_RS01690 341806..343188 + 1383 WP_010189798.1 protoporphyrinogen oxidase -
CAURI_RS01695 343383..343637 - 255 WP_010189797.1 Txe/YoeB family addiction module toxin Toxin
CAURI_RS01700 343643..343900 - 258 WP_010189796.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CAURI_RS01705 343968..345479 - 1512 WP_010189795.1 ATP-binding cassette domain-containing protein -
CAURI_RS01710 345564..346580 - 1017 WP_010189794.1 hypothetical protein -
CAURI_RS01715 346580..347158 - 579 WP_010189792.1 ATP-binding cassette domain-containing protein -
CAURI_RS13745 347377..347514 + 138 WP_010189784.1 hypothetical protein -
CAURI_RS13750 347571..347762 + 192 WP_012714808.1 hypothetical protein -
CAURI_RS01725 347803..348642 - 840 WP_029158964.1 NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10101.68 Da        Isoelectric Point: 9.4833

>T23759 WP_010189797.1 NC_012590:c343637-343383 [Corynebacterium aurimucosum ATCC 700975]
MILSWTEEAWEDYLWWQAHNKKILKRINSLIKDIARNGNEGIGKPEPLKFELAGFWSRRITEEHRLIYRIKGVTIEIAGC
RYHY

Download         Length: 255 bp

>T23759 NC_012590:c343637-343383 [Corynebacterium aurimucosum ATCC 700975]
ATGATTCTTTCGTGGACAGAGGAAGCGTGGGAGGACTACCTCTGGTGGCAAGCTCACAACAAGAAGATCCTCAAGAGAAT
CAATAGCCTCATTAAAGACATTGCACGAAACGGCAATGAAGGGATAGGAAAACCCGAACCACTCAAGTTCGAGTTAGCCG
GGTTCTGGTCTCGGCGAATTACGGAAGAGCACCGACTGATCTATCGCATTAAGGGCGTGACCATCGAGATTGCTGGGTGC
AGATACCACTACTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9703.66 Da        Isoelectric Point: 4.2497

>AT23759 WP_010189796.1 NC_012590:c343900-343643 [Corynebacterium aurimucosum ATCC 700975]
MKTMSYSESRARYAEVLQSVVDDREEVIITRSGHESAVIVSLDDYNSLRETAYLLRSPRNAQRLLDSIESLNTGEATEHE
LIEED

Download         Length: 258 bp

>AT23759 NC_012590:c343900-343643 [Corynebacterium aurimucosum ATCC 700975]
ATGAAAACCATGTCCTACTCGGAATCGCGAGCAAGATACGCCGAGGTCCTACAGTCAGTCGTTGATGACCGTGAAGAAGT
CATCATCACTCGCAGTGGTCATGAGTCTGCAGTCATCGTTTCCTTAGATGACTACAACTCTCTTCGCGAAACCGCTTACC
TTCTGCGTTCCCCTCGCAATGCGCAGCGCCTGCTTGACTCCATCGAGAGTCTCAACACCGGGGAAGCAACGGAGCACGAA
CTCATTGAGGAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N6TJV1

Antitoxin

Source ID Structure
AlphaFold DB C3PKH0

References