Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-dinJ/YafQ-RelB |
| Location | 57469..58000 | Replicon | plasmid unnamed |
| Accession | NZ_CP093029 | ||
| Organism | Pseudomonas aeruginosa strain H05 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A2K4Y311 |
| Locus tag | MMZ68_RS33555 | Protein ID | WP_023100672.1 |
| Coordinates | 57719..58000 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | W2D9V6 |
| Locus tag | MMZ68_RS33550 | Protein ID | WP_020303033.1 |
| Coordinates | 57469..57732 (+) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MMZ68_RS33520 (MMZ68_33520) | 53214..53480 | + | 267 | WP_071570749.1 | hypothetical protein | - |
| MMZ68_RS33525 (MMZ68_33525) | 53637..54134 | + | 498 | WP_228480184.1 | hypothetical protein | - |
| MMZ68_RS33530 (MMZ68_33530) | 54127..54303 | + | 177 | WP_153549643.1 | hypothetical protein | - |
| MMZ68_RS33535 (MMZ68_33535) | 54321..55679 | + | 1359 | WP_023100669.1 | replicative DNA helicase | - |
| MMZ68_RS33540 (MMZ68_33540) | 55679..56170 | + | 492 | WP_128549492.1 | hypothetical protein | - |
| MMZ68_RS33545 (MMZ68_33545) | 56402..57145 | + | 744 | WP_023100671.1 | glyoxalase superfamily protein | - |
| MMZ68_RS33550 (MMZ68_33550) | 57469..57732 | + | 264 | WP_020303033.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| MMZ68_RS33555 (MMZ68_33555) | 57719..58000 | + | 282 | WP_023100672.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| MMZ68_RS33560 (MMZ68_33560) | 58037..58372 | + | 336 | WP_023100673.1 | hypothetical protein | - |
| MMZ68_RS33565 (MMZ68_33565) | 58754..59206 | + | 453 | WP_023100674.1 | hypothetical protein | - |
| MMZ68_RS33570 (MMZ68_33570) | 59255..59977 | - | 723 | WP_031634065.1 | hypothetical protein | - |
| MMZ68_RS33575 (MMZ68_33575) | 59977..60327 | - | 351 | WP_023100676.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| MMZ68_RS33580 (MMZ68_33580) | 60324..60572 | - | 249 | WP_034017785.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| MMZ68_RS33585 (MMZ68_33585) | 60569..60988 | - | 420 | WP_057380713.1 | hypothetical protein | - |
| MMZ68_RS33590 (MMZ68_33590) | 61062..61538 | - | 477 | WP_034026837.1 | single-stranded DNA-binding protein | - |
| MMZ68_RS33595 (MMZ68_33595) | 61589..61987 | - | 399 | WP_176742248.1 | hypothetical protein | - |
| MMZ68_RS33600 (MMZ68_33600) | 61996..62679 | - | 684 | WP_034018055.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..143021 | 143021 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10724.19 Da Isoelectric Point: 9.0277
>T237589 WP_023100672.1 NZ_CP093029:57719-58000 [Pseudomonas aeruginosa]
MRTIEQTSRFKRDYKREAKGPHRQTLASDFVAIVTALANDQPLAEKHRDHALNGDWKDHRDCHIKPDLVLIYRKPDDAVL
QLVRLGSHSELGL
MRTIEQTSRFKRDYKREAKGPHRQTLASDFVAIVTALANDQPLAEKHRDHALNGDWKDHRDCHIKPDLVLIYRKPDDAVL
QLVRLGSHSELGL
Download Length: 282 bp
>T237589 NZ_LR882497:3183273-3183716 [Mycobacterium tuberculosis variant microti]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9471.95 Da Isoelectric Point: 4.8096
>AT237589 WP_020303033.1 NZ_CP093029:57469-57732 [Pseudomonas aeruginosa]
MSANAVVRARIDEHIKEEATVVLAAMGLTVSDAFRIMLTRVAREKALPFEPLIPNATTIEAMKEARRGGLKSFASVEDLM
ADLNADD
MSANAVVRARIDEHIKEEATVVLAAMGLTVSDAFRIMLTRVAREKALPFEPLIPNATTIEAMKEARRGGLKSFASVEDLM
ADLNADD
Download Length: 264 bp
>AT237589 NZ_LR882497:3183029-3183286 [Mycobacterium tuberculosis variant microti]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2K4Y311 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0W0N2R7 |