Detailed information of TA system TA237587

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 5698527..5699167
• Replicon: chromosome
• Accession: NZ_CP093028
• Organism: Pseudomonas aeruginosa strain H05

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MMZ68_RS26850
• Protein ID: WP_033945041.1
• Coordinates: 5698527..5698937 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MMZ68_RS26855
• Protein ID: WP_031634724.1
• Coordinates: 5698937..5699167 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ68_RS26810 (MMZ68_26810)	5694845..5695525	+	681	WP_154112681.1	hypothetical protein	-
MMZ68_RS26815 (MMZ68_26815)	5695538..5696266	+	729	WP_031275718.1	TIGR03761 family integrating conjugative element protein	-
MMZ68_RS26820 (MMZ68_26820)	5696272..5696805	+	534	WP_003134105.1	DUF3158 family protein	-
MMZ68_RS26825 (MMZ68_26825)	5696819..5697307	+	489	WP_003134107.1	single-stranded DNA-binding protein	-
MMZ68_RS26830 (MMZ68_26830)	5697411..5697605	+	195	WP_033945044.1	hypothetical protein	-
MMZ68_RS26835 (MMZ68_26835)	5697849..5698016	+	168	WP_128729268.1	CrpP family ICE-associated protein	-
MMZ68_RS26840 (MMZ68_26840)	5698082..5698300	-	219	WP_033945042.1	hypothetical protein	-
MMZ68_RS26845 (MMZ68_26845)	5698317..5698511	-	195	WP_023094845.1	hypothetical protein	-
MMZ68_RS26850 (MMZ68_26850)	5698527..5698937	-	411	WP_033945041.1	tRNA(fMet)-specific endonuclease VapC	Toxin
MMZ68_RS26855 (MMZ68_26855)	5698937..5699167	-	231	WP_031634724.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MMZ68_RS26860 (MMZ68_26860)	5699485..5701404	+	1920	WP_033945040.1	type I DNA topoisomerase	-
MMZ68_RS26865 (MMZ68_26865)	5701418..5702164	+	747	WP_058199490.1	hypothetical protein	-
MMZ68_RS26870 (MMZ68_26870)	5702281..5702886	-	606	WP_033945032.1	LysE family translocator	-
MMZ68_RS26875 (MMZ68_26875)	5703008..5703877	+	870	WP_023094849.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	katA	5680301..5812719	132418

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

• SpoVT-AbrB domain (7-33)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15452.83 Da
• Isoelectric Point: 7.9073

>T237587 WP_033945041.1 NZ_CP093028:c5698937-5698527 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKKRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQDAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Nucleotide

• Length: 411 bp

>T237587 NZ_LR882497:c3136903-3136511 [Mycobacterium tuberculosis variant microti]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8420.29 Da
• Isoelectric Point: 4.2821

>AT237587 WP_031634724.1 NZ_CP093028:c5699167-5698937 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Nucleotide

• Length: 231 bp

>AT237587 NZ_LR882497:c3137115-3136900 [Mycobacterium tuberculosis variant microti]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA