Detailed information of TA system TA237585

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4848516..4849774
• Replicon: chromosome
• Accession: NZ_CP093028
• Organism: Pseudomonas aeruginosa strain H05

Toxin (Protein)

• Gene name: -
• Uniprot ID: V6AJ34
• Locus tag: MMZ68_RS22695
• Protein ID: WP_003086331.1
• Coordinates: 4848516..4849271 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: MMZ68_RS22700
• Protein ID: WP_003086329.1
• Coordinates: 4849406..4849774 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ68_RS22685 (MMZ68_22685)	4843684..4846227	+	2544	WP_074198859.1	acyl-homoserine-lactone acylase QuiP	-
MMZ68_RS22690 (MMZ68_22690)	4846382..4847743	-	1362	WP_003134034.1	DNA recombination protein RmuC	-
MMZ68_RS22695 (MMZ68_22695)	4848516..4849271	-	756	WP_003086331.1	RES family NAD+ phosphorylase	Toxin
MMZ68_RS22700 (MMZ68_22700)	4849406..4849774	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
MMZ68_RS22705 (MMZ68_22705)	4849847..4851133	-	1287	WP_003086327.1	FAD-binding oxidoreductase	-
MMZ68_RS22710 (MMZ68_22710)	4851189..4852778	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
MMZ68_RS22715 (MMZ68_22715)	4852857..4853333	+	477	WP_019486191.1	elongation factor GreAB	-
MMZ68_RS22720 (MMZ68_22720)	4853336..4853611	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28236.34 Da
• Isoelectric Point: 7.7294

>T237585 WP_003086331.1 NZ_CP093028:c4849271-4848516 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T237585 NZ_LR882497:c3114462-3114106 [Mycobacterium tuberculosis variant microti]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT237585 WP_003086329.1 NZ_CP093028:c4849774-4849406 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT237585 NZ_LR882497:c3114676-3114446 [Mycobacterium tuberculosis variant microti]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Structures

Toxin

• AlphaFold DB: V6AJ34

Antitoxin

• AlphaFold DB: V6AJU7