Detailed information of TA system TA237584

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3900524..3901745
• Replicon: chromosome
• Accession: NZ_CP093028
• Organism: Pseudomonas aeruginosa strain H05

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0H2Z8V4
• Locus tag: MMZ68_RS18215
• Protein ID: WP_003110488.1
• Coordinates: 3901167..3901745 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MMZ68_RS18210
• Protein ID: WP_003088112.1
• Coordinates: 3900524..3901078 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ68_RS18185 (MMZ68_18185)	3896092..3896643	+	552	WP_019485487.1	XRE family transcriptional regulator	-
MMZ68_RS18190 (MMZ68_18190)	3896640..3897038	-	399	WP_019485486.1	NADH-quinone oxidoreductase subunit A	-
MMZ68_RS18195 (MMZ68_18195)	3897051..3897374	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
MMZ68_RS18200 (MMZ68_18200)	3897705..3898166	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
MMZ68_RS18205 (MMZ68_18205)	3898171..3900366	+	2196	WP_023091929.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
MMZ68_RS18210 (MMZ68_18210)	3900524..3901078	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
MMZ68_RS18215 (MMZ68_18215)	3901167..3901745	+	579	WP_003110488.1	HD domain-containing protein	Toxin
MMZ68_RS18220 (MMZ68_18220)	3901855..3903042	-	1188	WP_003110489.1	HlyD family efflux transporter periplasmic adaptor subunit	-
MMZ68_RS18225 (MMZ68_18225)	3903032..3905203	-	2172	WP_003088105.1	type I secretion system permease/ATPase	-
MMZ68_RS18230 (MMZ68_18230)	3905193..3906470	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21913.75 Da
• Isoelectric Point: 5.3655

>T237584 WP_003110488.1 NZ_CP093028:3901167-3901745 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T237584 NZ_LR882497:c3075221-3074826 [Mycobacterium tuberculosis variant microti]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT237584 WP_003088112.1 NZ_CP093028:3900524-3901078 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT237584 NZ_LR882497:c3074800-3074534 [Mycobacterium tuberculosis variant microti]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Structures

Toxin

• AlphaFold DB: A0A0H2Z8V4