Detailed information of TA system TA237581

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 150932..151437
• Replicon: chromosome
• Accession: NZ_CP093028
• Organism: Pseudomonas aeruginosa strain H05

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: MMZ68_RS00705
• Protein ID: WP_003083773.1
• Coordinates: 150932..151213 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: MMZ68_RS00710
• Protein ID: WP_003083775.1
• Coordinates: 151210..151437 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ68_RS00680 (MMZ68_00680)	146183..147532	+	1350	WP_003137006.1	C4-dicarboxylate transporter DctA	-
MMZ68_RS00685 (MMZ68_00685)	147581..148267	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MMZ68_RS00690 (MMZ68_00690)	148368..149102	+	735	WP_003110658.1	GntR family transcriptional regulator	-
MMZ68_RS00695 (MMZ68_00695)	149282..149692	+	411	WP_003110659.1	aegerolysin family protein	-
MMZ68_RS00700 (MMZ68_00700)	149724..150632	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MMZ68_RS00705 (MMZ68_00705)	150932..151213	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
MMZ68_RS00710 (MMZ68_00710)	151210..151437	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
MMZ68_RS00715 (MMZ68_00715)	151613..152236	-	624	WP_003137011.1	hypothetical protein	-
MMZ68_RS00720 (MMZ68_00720)	152337..152837	+	501	WP_003101228.1	LEA type 2 family protein	-
MMZ68_RS00725 (MMZ68_00725)	152909..153250	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MMZ68_RS00730 (MMZ68_00730)	153332..154759	-	1428	WP_003083784.1	GABA permease	-
MMZ68_RS00735 (MMZ68_00735)	154928..156421	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T237581 WP_003083773.1 NZ_CP093028:c151213-150932 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T237581 NZ_LR882497:2934321-2934761 [Mycobacterium tuberculosis variant microti]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT237581 WP_003083775.1 NZ_CP093028:c151437-151210 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT237581 NZ_LR882497:2934047-2934334 [Mycobacterium tuberculosis variant microti]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9