Detailed information of TA system TA237579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4447879..4449137
• Replicon: chromosome
• Accession: NZ_CP093023
• Organism: Pseudomonas aeruginosa strain H07

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MMZ70_RS20445
• Protein ID: WP_012614407.1
• Coordinates: 4447879..4448634 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MMZ70_RS20450
• Protein ID: WP_104052917.1
• Coordinates: 4448769..4449137 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ70_RS20435 (MMZ70_20445)	4443052..4445595	+	2544	WP_019682207.1	acyl-homoserine-lactone acylase QuiP	-
MMZ70_RS20440 (MMZ70_20450)	4445750..4447111	-	1362	WP_073666947.1	DNA recombination protein RmuC	-
MMZ70_RS20445 (MMZ70_20455)	4447879..4448634	-	756	WP_012614407.1	RES family NAD+ phosphorylase	Toxin
MMZ70_RS20450 (MMZ70_20460)	4448769..4449137	-	369	WP_104052917.1	DUF2384 domain-containing protein	Antitoxin
MMZ70_RS20455 (MMZ70_20465)	4449210..4450496	-	1287	WP_012614408.1	FAD-binding oxidoreductase	-
MMZ70_RS20460 (MMZ70_20470)	4450552..4452141	-	1590	WP_003125055.1	aldehyde dehydrogenase family protein	-
MMZ70_RS20465 (MMZ70_20475)	4452220..4452696	+	477	WP_003112531.1	hypothetical protein	-
MMZ70_RS20470 (MMZ70_20480)	4452699..4452974	-	276	WP_169057979.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28250.37 Da
• Isoelectric Point: 7.7294

>T237579 WP_012614407.1 NZ_CP093023:c4448634-4447879 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T237579 NZ_LR882497:2872814-2873191 [Mycobacterium tuberculosis variant microti]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.58 Da
• Isoelectric Point: 9.6217

>AT237579 WP_104052917.1 NZ_CP093023:c4449137-4448769 [Pseudomonas aeruginosa]
MSALIQERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT237579 NZ_LR882497:2872560-2872817 [Mycobacterium tuberculosis variant microti]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA