Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4447879..4449137 Replicon chromosome
Accession NZ_CP093023
Organism Pseudomonas aeruginosa strain H07

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MMZ70_RS20445 Protein ID WP_012614407.1
Coordinates 4447879..4448634 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MMZ70_RS20450 Protein ID WP_104052917.1
Coordinates 4448769..4449137 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ70_RS20435 (MMZ70_20445) 4443052..4445595 + 2544 WP_019682207.1 acyl-homoserine-lactone acylase QuiP -
MMZ70_RS20440 (MMZ70_20450) 4445750..4447111 - 1362 WP_073666947.1 DNA recombination protein RmuC -
MMZ70_RS20445 (MMZ70_20455) 4447879..4448634 - 756 WP_012614407.1 RES family NAD+ phosphorylase Toxin
MMZ70_RS20450 (MMZ70_20460) 4448769..4449137 - 369 WP_104052917.1 DUF2384 domain-containing protein Antitoxin
MMZ70_RS20455 (MMZ70_20465) 4449210..4450496 - 1287 WP_012614408.1 FAD-binding oxidoreductase -
MMZ70_RS20460 (MMZ70_20470) 4450552..4452141 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
MMZ70_RS20465 (MMZ70_20475) 4452220..4452696 + 477 WP_003112531.1 hypothetical protein -
MMZ70_RS20470 (MMZ70_20480) 4452699..4452974 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T237579 WP_012614407.1 NZ_CP093023:c4448634-4447879 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

>T237579 NZ_LR882497:2872814-2873191 [Mycobacterium tuberculosis variant microti]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.58 Da        Isoelectric Point: 9.6217

>AT237579 WP_104052917.1 NZ_CP093023:c4449137-4448769 [Pseudomonas aeruginosa]
MSALIQERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT237579 NZ_LR882497:2872560-2872817 [Mycobacterium tuberculosis variant microti]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References