Detailed information of TA system TA237578

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3520913..3522134
• Replicon: chromosome
• Accession: NZ_CP093023
• Organism: Pseudomonas aeruginosa strain H07

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: MMZ70_RS16120
• Protein ID: WP_003102740.1
• Coordinates: 3521556..3522134 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MMZ70_RS16115
• Protein ID: WP_003088112.1
• Coordinates: 3520913..3521467 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ70_RS16090 (MMZ70_16100)	3516481..3517032	+	552	WP_003102727.1	XRE family transcriptional regulator	-
MMZ70_RS16095 (MMZ70_16105)	3517029..3517427	-	399	WP_023082958.1	NADH-quinone oxidoreductase subunit A	-
MMZ70_RS16100 (MMZ70_16110)	3517440..3517763	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
MMZ70_RS16105 (MMZ70_16115)	3518094..3518555	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
MMZ70_RS16110 (MMZ70_16120)	3518560..3520755	+	2196	WP_104052858.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
MMZ70_RS16115 (MMZ70_16125)	3520913..3521467	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
MMZ70_RS16120 (MMZ70_16130)	3521556..3522134	+	579	WP_003102740.1	HD domain-containing protein	Toxin
MMZ70_RS16125 (MMZ70_16135)	3522243..3523430	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
MMZ70_RS16130 (MMZ70_16140)	3523420..3525591	-	2172	WP_009876279.1	type I secretion system permease/ATPase	-
MMZ70_RS16135 (MMZ70_16145)	3525581..3526858	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T237578 WP_003102740.1 NZ_CP093023:3521556-3522134 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T237578 NZ_LR882497:2872108-2872521 [Mycobacterium tuberculosis variant microti]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT237578 WP_003088112.1 NZ_CP093023:3520913-3521467 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT237578 NZ_LR882497:2872560-2872817 [Mycobacterium tuberculosis variant microti]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07