Detailed information of TA system TA237576

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 145302..145807
• Replicon: chromosome
• Accession: NZ_CP093023
• Organism: Pseudomonas aeruginosa strain H07

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: MMZ70_RS00680
• Protein ID: WP_003083773.1
• Coordinates: 145302..145583 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q9I707
• Locus tag: MMZ70_RS00685
• Protein ID: WP_003112628.1
• Coordinates: 145580..145807 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ70_RS00655 (MMZ70_00655)	140553..141902	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
MMZ70_RS00660 (MMZ70_00660)	141951..142637	+	687	WP_004351997.1	FadR/GntR family transcriptional regulator	-
MMZ70_RS00665 (MMZ70_00665)	142738..143472	+	735	WP_003117208.1	GntR family transcriptional regulator	-
MMZ70_RS00670 (MMZ70_00670)	143652..144062	+	411	WP_003101225.1	aegerolysin family protein	-
MMZ70_RS00675 (MMZ70_00675)	144094..145002	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MMZ70_RS00680 (MMZ70_00680)	145302..145583	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
MMZ70_RS00685 (MMZ70_00685)	145580..145807	-	228	WP_003112628.1	CopG family ribbon-helix-helix protein	Antitoxin
MMZ70_RS00690 (MMZ70_00690)	145982..146602	-	621	WP_009314940.1	hypothetical protein	-
MMZ70_RS00695 (MMZ70_00695)	146710..147210	+	501	WP_003112629.1	LEA type 2 family protein	-
MMZ70_RS00700 (MMZ70_00700)	147283..147624	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MMZ70_RS00705 (MMZ70_00705)	147706..149133	-	1428	WP_003083784.1	GABA permease	-
MMZ70_RS00710 (MMZ70_00710)	149302..150795	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T237576 WP_003083773.1 NZ_CP093023:c145583-145302 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T237576 NZ_LR882497:2812270-2812695 [Mycobacterium tuberculosis variant microti]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8568.64 Da
• Isoelectric Point: 5.5740

>AT237576 WP_003112628.1 NZ_CP093023:c145807-145580 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT237576 NZ_LR882497:2812043-2812264 [Mycobacterium tuberculosis variant microti]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: Q9I707