Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5163777..5164385 Replicon chromosome
Accession NZ_CP093022
Organism Pseudomonas aeruginosa strain H08

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag MMZ71_RS24365 Protein ID WP_003123043.1
Coordinates 5163777..5164124 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag MMZ71_RS24370 Protein ID WP_003114155.1
Coordinates 5164134..5164385 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ71_RS24345 (MMZ71_24350) 5159711..5160208 + 498 Protein_4827 heat resistance protein PsiE-GI -
MMZ71_RS24350 (MMZ71_24355) 5160186..5161151 + 966 WP_003141083.1 zinc metalloprotease HtpX -
MMZ71_RS24355 (MMZ71_24360) 5161176..5162327 + 1152 WP_012761372.1 trypsin-like peptidase domain-containing protein -
MMZ71_RS24360 (MMZ71_24365) 5162560..5163468 + 909 WP_003141085.1 LysR family transcriptional regulator -
MMZ71_RS24365 (MMZ71_24370) 5163777..5164124 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MMZ71_RS24370 (MMZ71_24375) 5164134..5164385 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MMZ71_RS24375 (MMZ71_24380) 5164599..5165582 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
MMZ71_RS24380 (MMZ71_24385) 5165582..5166874 - 1293 WP_003123045.1 hypothetical protein -
MMZ71_RS24385 (MMZ71_24390) 5167104..5168378 - 1275 WP_058154821.1 zonular occludens toxin family protein -
MMZ71_RS24390 (MMZ71_24395) 5168382..5168738 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5151347..5179199 27852


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T237574 WP_003123043.1 NZ_CP093022:c5164124-5163777 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T237574 NZ_LR882497:c2372351-2371917 [Mycobacterium tuberculosis variant microti]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT237574 WP_003114155.1 NZ_CP093022:c5164385-5164134 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT237574 NZ_LR882497:c2372612-2372358 [Mycobacterium tuberculosis variant microti]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References