Detailed information of TA system TA237572

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4692841..4694099
• Replicon: chromosome
• Accession: NZ_CP093022
• Organism: Pseudomonas aeruginosa strain H08

Toxin (Protein)

• Gene name: -
• Uniprot ID: V6AJ34
• Locus tag: MMZ71_RS21955
• Protein ID: WP_003086331.1
• Coordinates: 4692841..4693596 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: MMZ71_RS21960
• Protein ID: WP_003086329.1
• Coordinates: 4693731..4694099 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ71_RS21945 (MMZ71_21950)	4688013..4690556	+	2544	WP_003134033.1	acyl-homoserine-lactone acylase QuiP	-
MMZ71_RS21950 (MMZ71_21955)	4690711..4692072	-	1362	WP_073647918.1	DNA recombination protein RmuC	-
MMZ71_RS21955 (MMZ71_21960)	4692841..4693596	-	756	WP_003086331.1	RES family NAD+ phosphorylase	Toxin
MMZ71_RS21960 (MMZ71_21965)	4693731..4694099	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
MMZ71_RS21965 (MMZ71_21970)	4694172..4695458	-	1287	WP_003086327.1	FAD-binding oxidoreductase	-
MMZ71_RS21970 (MMZ71_21975)	4695514..4697103	-	1590	WP_079380854.1	aldehyde dehydrogenase family protein	-
MMZ71_RS21975 (MMZ71_21980)	4697181..4697657	+	477	WP_003086322.1	hypothetical protein	-
MMZ71_RS21980 (MMZ71_21985)	4697660..4697935	-	276	WP_171410771.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28236.34 Da
• Isoelectric Point: 7.7294

>T237572 WP_003086331.1 NZ_CP093022:c4693596-4692841 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T237572 NZ_LR882497:2259113-2259511 [Mycobacterium tuberculosis variant microti]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT237572 WP_003086329.1 NZ_CP093022:c4694099-4693731 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT237572 NZ_LR882497:2258885-2259112 [Mycobacterium tuberculosis variant microti]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCGACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Structures

Toxin

• AlphaFold DB: V6AJ34

Antitoxin

• AlphaFold DB: V6AJU7