Detailed information of TA system TA237571

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3743054..3744274
• Replicon: chromosome
• Accession: NZ_CP093022
• Organism: Pseudomonas aeruginosa strain H08

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0H2Z8V4
• Locus tag: MMZ71_RS17505
• Protein ID: WP_003110488.1
• Coordinates: 3743696..3744274 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MMZ71_RS17500
• Protein ID: WP_003088112.1
• Coordinates: 3743054..3743608 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ71_RS17475 (MMZ71_17480)	3738622..3739173	+	552	WP_003139878.1	XRE family transcriptional regulator	-
MMZ71_RS17480 (MMZ71_17485)	3739170..3739568	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
MMZ71_RS17485 (MMZ71_17490)	3739581..3739904	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
MMZ71_RS17490 (MMZ71_17495)	3740235..3740696	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
MMZ71_RS17495 (MMZ71_17500)	3740701..3742896	+	2196	WP_023875495.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
MMZ71_RS17500 (MMZ71_17505)	3743054..3743608	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
MMZ71_RS17505 (MMZ71_17510)	3743696..3744274	+	579	WP_003110488.1	HD domain-containing protein	Toxin
MMZ71_RS17510 (MMZ71_17515)	3744383..3745570	-	1188	WP_003088106.1	HlyD family efflux transporter periplasmic adaptor subunit	-
MMZ71_RS17515 (MMZ71_17520)	3745560..3747731	-	2172	WP_023106617.1	type I secretion system permease/ATPase	-
MMZ71_RS17520 (MMZ71_17525)	3747721..3748998	-	1278	WP_003088104.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21913.75 Da
• Isoelectric Point: 5.3655

>T237571 WP_003110488.1 NZ_CP093022:3743696-3744274 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T237571 NZ_LR882497:c2235489-2235145 [Mycobacterium tuberculosis variant microti]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT237571 WP_003088112.1 NZ_CP093022:3743054-3743608 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT237571 NZ_LR882497:c2235731-2235483 [Mycobacterium tuberculosis variant microti]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Structures

Toxin

• AlphaFold DB: A0A0H2Z8V4