Detailed information of TA system TA237568

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 143245..143750
• Replicon: chromosome
• Accession: NZ_CP093022
• Organism: Pseudomonas aeruginosa strain H08

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: MMZ71_RS00665
• Protein ID: WP_003083773.1
• Coordinates: 143245..143526 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: MMZ71_RS00670
• Protein ID: WP_003083775.1
• Coordinates: 143523..143750 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ71_RS00640 (MMZ71_00640)	138496..139845	+	1350	WP_003137006.1	C4-dicarboxylate transporter DctA	-
MMZ71_RS00645 (MMZ71_00645)	139894..140580	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MMZ71_RS00650 (MMZ71_00650)	140681..141415	+	735	WP_003110658.1	GntR family transcriptional regulator	-
MMZ71_RS00655 (MMZ71_00655)	141595..142005	+	411	WP_003110659.1	aegerolysin family protein	-
MMZ71_RS00660 (MMZ71_00660)	142037..142945	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MMZ71_RS00665 (MMZ71_00665)	143245..143526	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
MMZ71_RS00670 (MMZ71_00670)	143523..143750	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
MMZ71_RS00675 (MMZ71_00675)	143926..144549	-	624	WP_003137011.1	hypothetical protein	-
MMZ71_RS00680 (MMZ71_00680)	144650..145150	+	501	WP_033954848.1	LEA type 2 family protein	-
MMZ71_RS00685 (MMZ71_00685)	145223..145564	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MMZ71_RS00690 (MMZ71_00690)	145646..147073	-	1428	WP_003083784.1	GABA permease	-
MMZ71_RS00695 (MMZ71_00695)	147242..148735	-	1494	WP_023098308.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T237568 WP_003083773.1 NZ_CP093022:c143526-143245 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T237568 NZ_LR882497:c2218050-2217754 [Mycobacterium tuberculosis variant microti]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT237568 WP_003083775.1 NZ_CP093022:c143750-143523 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT237568 NZ_LR882497:c2218298-2218047 [Mycobacterium tuberculosis variant microti]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9