Detailed information of TA system TA237566

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4371867..4373124
• Replicon: chromosome
• Accession: NZ_CP093021
• Organism: Pseudomonas aeruginosa strain H09

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MMZ72_RS20065
• Protein ID: WP_058140803.1
• Coordinates: 4371867..4372622 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: MMZ72_RS20070
• Protein ID: WP_003086329.1
• Coordinates: 4372756..4373124 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ72_RS20055 (MMZ72_20055)	4367041..4369584	+	2544	WP_121501271.1	acyl-homoserine-lactone acylase QuiP	-
MMZ72_RS20060 (MMZ72_20060)	4369734..4371095	-	1362	WP_079752925.1	DNA recombination protein RmuC	-
MMZ72_RS20065 (MMZ72_20065)	4371867..4372622	-	756	WP_058140803.1	RES family NAD+ phosphorylase	Toxin
MMZ72_RS20070 (MMZ72_20070)	4372756..4373124	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
MMZ72_RS20075 (MMZ72_20075)	4373197..4374486	-	1290	WP_241469083.1	FAD-binding oxidoreductase	-
MMZ72_RS20080 (MMZ72_20080)	4374542..4376131	-	1590	WP_121129154.1	aldehyde dehydrogenase family protein	-
MMZ72_RS20085 (MMZ72_20085)	4376208..4376684	+	477	WP_241469084.1	GreA/GreB family elongation factor	-
MMZ72_RS20090 (MMZ72_20090)	4376687..4376962	-	276	WP_049942684.1	zinc ribbon domain-containing protein	-
MMZ72_RS20095 (MMZ72_20095)	4377096..4377474	-	379	Protein_3983	OprD family porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28341.52 Da
• Isoelectric Point: 7.7279

>T237566 WP_058140803.1 NZ_CP093021:c4372622-4371867 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLHVPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPVAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPYPA

Nucleotide

• Length: 756 bp

>T237566 NZ_LR882497:c2209046-2208717 [Mycobacterium tuberculosis variant microti]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT237566 WP_003086329.1 NZ_CP093021:c4373124-4372756 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT237566 NZ_LR882497:c2209420-2209043 [Mycobacterium tuberculosis variant microti]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7