237565

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3479150..3480371 Replicon chromosome
Accession NZ_CP093021
Organism Pseudomonas aeruginosa strain H09

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MMZ72_RS15915 Protein ID WP_024918215.1
Coordinates 3479793..3480371 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MMZ72_RS15910 Protein ID WP_024918216.1
Coordinates 3479150..3479704 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ72_RS15885 (MMZ72_15885) 3474719..3475270 + 552 WP_121305624.1 XRE family transcriptional regulator -
MMZ72_RS15890 (MMZ72_15890) 3475267..3475665 - 399 WP_024918219.1 NADH-quinone oxidoreductase subunit A -
MMZ72_RS15895 (MMZ72_15895) 3475678..3476001 - 324 WP_023106612.1 multidrug efflux SMR transporter -
MMZ72_RS15900 (MMZ72_15900) 3476332..3476793 + 462 WP_024918218.1 (2Fe-2S)-binding protein -
MMZ72_RS15905 (MMZ72_15905) 3476798..3478993 + 2196 WP_124126988.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
MMZ72_RS15910 (MMZ72_15910) 3479150..3479704 + 555 WP_024918216.1 helix-turn-helix transcriptional regulator Antitoxin
MMZ72_RS15915 (MMZ72_15915) 3479793..3480371 + 579 WP_024918215.1 HD domain-containing protein Toxin
MMZ72_RS15920 (MMZ72_15920) 3480498..3481580 + 1083 WP_024918214.1 FAD-binding oxidoreductase -
MMZ72_RS15925 (MMZ72_15925) 3481735..3482922 - 1188 WP_024918213.1 HlyD family efflux transporter periplasmic adaptor subunit -
MMZ72_RS15930 (MMZ72_15930) 3482912..3485083 - 2172 WP_121129777.1 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.70 Da        Isoelectric Point: 5.0263

>T237565 WP_024918215.1 NZ_CP093021:3479793-3480371 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRERLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLEAQRDA

Download         Length: 579 bp

>T237565 NZ_LR882497:1970981-1971229 [Mycobacterium tuberculosis variant microti]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATACGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20458.62 Da        Isoelectric Point: 8.5375

>AT237565 WP_024918216.1 NZ_CP093021:3479150-3479704 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLLEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGDLLGRSLWPYCSEEILRQETTLEDLGWRELLAPPTLEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT237565 NZ_LR882497:1970769-1970981 [Mycobacterium tuberculosis variant microti]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References