237563

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 139122..139627 Replicon chromosome
Accession NZ_CP093021
Organism Pseudomonas aeruginosa strain H09

Toxin (Protein)


Gene name parE Uniprot ID A0A3S0LZE8
Locus tag MMZ72_RS00640 Protein ID WP_003156094.1
Coordinates 139122..139403 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag MMZ72_RS00645 Protein ID WP_003083775.1
Coordinates 139400..139627 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ72_RS00615 (MMZ72_00615) 134368..135717 + 1350 WP_079752987.1 C4-dicarboxylate transporter DctA -
MMZ72_RS00620 (MMZ72_00620) 135766..136452 + 687 WP_058138883.1 FadR/GntR family transcriptional regulator -
MMZ72_RS00625 (MMZ72_00625) 136554..137288 + 735 WP_024916686.1 GntR family transcriptional regulator -
MMZ72_RS00630 (MMZ72_00630) 137468..137878 + 411 WP_024916685.1 aegerolysin family protein -
MMZ72_RS00635 (MMZ72_00635) 137913..138821 - 909 WP_024916684.1 LysR family transcriptional regulator -
MMZ72_RS00640 (MMZ72_00640) 139122..139403 - 282 WP_003156094.1 type II toxin-antitoxin system toxin ParE Toxin
MMZ72_RS00645 (MMZ72_00645) 139400..139627 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
MMZ72_RS00650 (MMZ72_00650) 139803..140423 - 621 WP_121129709.1 hypothetical protein -
MMZ72_RS00655 (MMZ72_00655) 140524..141024 + 501 WP_024916682.1 LEA type 2 family protein -
MMZ72_RS00660 (MMZ72_00660) 141097..141438 + 342 WP_024916681.1 zinc ribbon domain-containing protein YjdM -
MMZ72_RS00665 (MMZ72_00665) 141558..142985 - 1428 WP_058138879.1 GABA permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10433.15 Da        Isoelectric Point: 9.6558

>T237563 WP_003156094.1 NZ_CP093021:c139403-139122 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQEVANQGAGRPSEVPGVRTLALERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T237563 NZ_LR882497:1777125-1777529 [Mycobacterium tuberculosis variant microti]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT237563 WP_003083775.1 NZ_CP093021:c139627-139400 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT237563 NZ_LR882497:1776916-1777119 [Mycobacterium tuberculosis variant microti]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0LZE8

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References