Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 5094632..5095527 | Replicon | chromosome |
| Accession | NZ_CP093020 | ||
| Organism | Pseudomonas aeruginosa strain H10 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A318E8F0 |
| Locus tag | MMZ73_RS24115 | Protein ID | WP_023093160.1 |
| Coordinates | 5094632..5095159 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A318DY98 |
| Locus tag | MMZ73_RS24120 | Protein ID | WP_023093161.1 |
| Coordinates | 5095156..5095527 (-) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MMZ73_RS24095 (MMZ73_24110) | 5090425..5092440 | - | 2016 | WP_023093157.1 | DNA topoisomerase III | - |
| MMZ73_RS24100 (MMZ73_24115) | 5092735..5093118 | - | 384 | WP_004362284.1 | single-stranded DNA-binding protein | - |
| MMZ73_RS24105 (MMZ73_24120) | 5093115..5093663 | - | 549 | WP_023093158.1 | DUF3158 family protein | - |
| MMZ73_RS24110 (MMZ73_24125) | 5093660..5094448 | - | 789 | WP_023093159.1 | TIGR03761 family integrating conjugative element protein | - |
| MMZ73_RS24115 (MMZ73_24130) | 5094632..5095159 | - | 528 | WP_023093160.1 | RES family NAD+ phosphorylase | Toxin |
| MMZ73_RS24120 (MMZ73_24135) | 5095156..5095527 | - | 372 | WP_023093161.1 | hypothetical protein | Antitoxin |
| MMZ73_RS24125 (MMZ73_24140) | 5095648..5096841 | - | 1194 | WP_023093162.1 | STY4528 family pathogenicity island replication protein | - |
| MMZ73_RS24130 (MMZ73_24145) | 5096845..5097405 | - | 561 | WP_023093163.1 | DUF2857 domain-containing protein | - |
| MMZ73_RS24135 (MMZ73_24150) | 5097423..5099081 | - | 1659 | WP_023093164.1 | ParB family protein | - |
| MMZ73_RS24140 (MMZ73_24155) | 5099074..5099310 | - | 237 | WP_012584779.1 | hypothetical protein | - |
| MMZ73_RS24145 (MMZ73_24160) | 5099294..5100160 | - | 867 | WP_023093165.1 | ParA family protein | - |
| MMZ73_RS24150 (MMZ73_24165) | 5100201..5100419 | - | 219 | WP_016446183.1 | AlpA family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 4983720..5126329 | 142609 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19831.28 Da Isoelectric Point: 5.2440
>T237561 WP_023093160.1 NZ_CP093020:c5095159-5094632 [Pseudomonas aeruginosa]
MILLDLPPGTTLFRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLEEATALREYQQTSPFLPPCTMCSYTVALREL
VDLRQLHRGEPWDELWHDWREDWRHLKFDLHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNIVVFVDRLRDGNSVEVN
DPDGRLPRDQSSWTR
MILLDLPPGTTLFRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLEEATALREYQQTSPFLPPCTMCSYTVALREL
VDLRQLHRGEPWDELWHDWREDWRHLKFDLHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNIVVFVDRLRDGNSVEVN
DPDGRLPRDQSSWTR
Download Length: 528 bp
>T237561 NZ_LR882497:c1583877-1583476 [Mycobacterium tuberculosis variant microti]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGGCCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGGCCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA
Antitoxin
Download Length: 124 a.a. Molecular weight: 13358.05 Da Isoelectric Point: 6.0705
>AT237561 WP_023093161.1 NZ_CP093020:c5095527-5095156 [Pseudomonas aeruginosa]
MASTAFADVLESVREAGTSRFSATNVADALGLQYQDLATLAGVHRNTLRTHPESPRLQAALRDLMRVLSAASAVQPDTAR
AFFMVKNEPIPTFHHKTLLQLVQEGRTDDAIDYLESISAGFTG
MASTAFADVLESVREAGTSRFSATNVADALGLQYQDLATLAGVHRNTLRTHPESPRLQAALRDLMRVLSAASAVQPDTAR
AFFMVKNEPIPTFHHKTLLQLVQEGRTDDAIDYLESISAGFTG
Download Length: 372 bp
>AT237561 NZ_LR882497:c1584131-1583874 [Mycobacterium tuberculosis variant microti]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A318E8F0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A318DY98 |