237559

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3616766..3617987 Replicon chromosome
Accession NZ_CP093020
Organism Pseudomonas aeruginosa strain H10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MMZ73_RS16880 Protein ID WP_003160088.1
Coordinates 3617409..3617987 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MMZ73_RS16875 Protein ID WP_003088112.1
Coordinates 3616766..3617320 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ73_RS16850 (MMZ73_16865) 3612334..3612885 + 552 WP_003102727.1 XRE family transcriptional regulator -
MMZ73_RS16855 (MMZ73_16870) 3612882..3613280 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
MMZ73_RS16860 (MMZ73_16875) 3613293..3613616 - 324 WP_003102734.1 multidrug efflux SMR transporter -
MMZ73_RS16865 (MMZ73_16880) 3613947..3614408 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
MMZ73_RS16870 (MMZ73_16885) 3614413..3616608 + 2196 WP_003160090.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
MMZ73_RS16875 (MMZ73_16890) 3616766..3617320 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
MMZ73_RS16880 (MMZ73_16895) 3617409..3617987 + 579 WP_003160088.1 HD domain-containing protein Toxin
MMZ73_RS16885 (MMZ73_16900) 3618096..3619283 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
MMZ73_RS16890 (MMZ73_16905) 3619273..3621444 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
MMZ73_RS16895 (MMZ73_16910) 3621434..3622711 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T237559 WP_003160088.1 NZ_CP093020:3617409-3617987 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T237559 NZ_LR882497:c1393566-1393273 [Mycobacterium tuberculosis variant microti]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT237559 WP_003088112.1 NZ_CP093020:3616766-3617320 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT237559 NZ_LR882497:c1393832-1393563 [Mycobacterium tuberculosis variant microti]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References