Detailed information of TA system TA237557

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1346001..1346671
• Replicon: chromosome
• Accession: NZ_CP093020
• Organism: Pseudomonas aeruginosa strain H10

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MMZ73_RS06395
• Protein ID: WP_023114647.1
• Coordinates: 1346252..1346671 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MMZ73_RS06390
• Protein ID: WP_023114648.1
• Coordinates: 1346001..1346255 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ73_RS06370 (MMZ73_06370)	1341542..1342534	-	993	WP_023114651.1	hypothetical protein	-
MMZ73_RS06375 (MMZ73_06375)	1342628..1342852	+	225	WP_023114650.1	AlpA family phage regulatory protein	-
MMZ73_RS06380 (MMZ73_06380)	1342855..1343748	+	894	WP_031637438.1	helicase RepA family protein	-
MMZ73_RS06385 (MMZ73_06385)	1343729..1344706	+	978	WP_031637437.1	replication protein C, IncQ-type	-
MMZ73_RS06390 (MMZ73_06390)	1346001..1346255	+	255	WP_023114648.1	Arc family DNA-binding protein	Antitoxin
MMZ73_RS06395 (MMZ73_06395)	1346252..1346671	+	420	WP_023114647.1	type II toxin-antitoxin system VapC family toxin	Toxin
MMZ73_RS06400 (MMZ73_06400)	1346827..1347597	+	771	WP_023114646.1	P-type conjugative transfer protein TrbJ	-
MMZ73_RS06405 (MMZ73_06405)	1347611..1347769	+	159	WP_023114645.1	hypothetical protein	-
MMZ73_RS06410 (MMZ73_06410)	1347771..1349243	+	1473	WP_023114644.1	P-type conjugative transfer protein TrbL	-
MMZ73_RS06415 (MMZ73_06415)	1349312..1349554	+	243	WP_023114643.1	type I toxin-antitoxin system ptaRNA1 family toxin	-
MMZ73_RS06420 (MMZ73_06420)	1349566..1349850	+	285	WP_023114642.1	hypothetical protein	-
MMZ73_RS06425 (MMZ73_06425)	1349853..1350221	+	369	WP_023114641.1	conjugal transfer transcriptional regulator TraJ	-
MMZ73_RS06430 (MMZ73_06430)	1350260..1350490	-	231	WP_229033214.1	hypothetical protein	-
MMZ73_RS06435 (MMZ73_06435)	1350470..1350718	-	249	Protein_1275	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1341542..1361153	19611

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14925.16 Da
• Isoelectric Point: 5.1890

>T237557 WP_023114647.1 NZ_CP093020:1346252-1346671 [Pseudomonas aeruginosa]
MIVLDTNVVSEAMKPEPNPAVRAWLNEQVVETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFGERVLMFDTE
AARHYAELAVKARTAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHQ

Nucleotide

• Length: 420 bp

>T237557 NZ_LR882497:1242823-1243197 [Mycobacterium tuberculosis variant microti]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9508.87 Da
• Isoelectric Point: 6.4760

>AT237557 WP_023114648.1 NZ_CP093020:1346001-1346255 [Pseudomonas aeruginosa]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSEKRIRMGDALAELGRRVGLTNDDFAVLDQVRDKVPAEP
MRFE

Nucleotide

• Length: 255 bp

>AT237557 NZ_LR882497:1242629-1242826 [Mycobacterium tuberculosis variant microti]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA