Detailed information of TA system TA237556

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 148132..148637
• Replicon: chromosome
• Accession: NZ_CP093020
• Organism: Pseudomonas aeruginosa strain H10

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MMZ73_RS00680
• Protein ID: WP_023114790.1
• Coordinates: 148132..148413 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: MMZ73_RS00685
• Protein ID: WP_003083775.1
• Coordinates: 148410..148637 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ73_RS00655 (MMZ73_00655)	143383..144732	+	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-
MMZ73_RS00660 (MMZ73_00660)	144781..145467	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MMZ73_RS00665 (MMZ73_00665)	145568..146302	+	735	WP_003117208.1	GntR family transcriptional regulator	-
MMZ73_RS00670 (MMZ73_00670)	146482..146892	+	411	WP_003101225.1	aegerolysin family protein	-
MMZ73_RS00675 (MMZ73_00675)	146924..147832	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MMZ73_RS00680 (MMZ73_00680)	148132..148413	-	282	WP_023114790.1	type II toxin-antitoxin system toxin ParE	Toxin
MMZ73_RS00685 (MMZ73_00685)	148410..148637	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
MMZ73_RS00690 (MMZ73_00690)	148813..149433	-	621	WP_003101226.1	hypothetical protein	-
MMZ73_RS00695 (MMZ73_00695)	149534..150034	+	501	WP_003101228.1	LEA type 2 family protein	-
MMZ73_RS00700 (MMZ73_00700)	150107..150448	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MMZ73_RS00705 (MMZ73_00705)	150530..151957	-	1428	WP_003083784.1	GABA permease	-
MMZ73_RS00710 (MMZ73_00710)	152126..153619	-	1494	WP_016263977.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10464.21 Da
• Isoelectric Point: 10.0014

>T237556 WP_023114790.1 NZ_CP093020:c148413-148132 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDKVEITP

Nucleotide

• Length: 282 bp

>T237556 NZ_LR882497:c1234184-1233873 [Mycobacterium tuberculosis variant microti]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT237556 WP_003083775.1 NZ_CP093020:c148637-148410 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT237556 NZ_LR882497:c1234504-1234184 [Mycobacterium tuberculosis variant microti]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9