Detailed information of TA system TA237555

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 369591..370284
• Replicon: plasmid unnamed
• Accession: NZ_CP093017
• Organism: Pseudomonas aeruginosa strain H15

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: MMZ75_RS33965
• Protein ID: WP_203788600.1
• Coordinates: 369907..370284 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: MMZ75_RS33960
• Protein ID: WP_203788597.1
• Coordinates: 369591..369926 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ75_RS33935 (MMZ75_33945)	365448..366728	-	1281	WP_241474442.1	acyl-CoA dehydrogenase family protein	-
MMZ75_RS33940 (MMZ75_33950)	367127..368357	-	1231	Protein_429	HD-GYP domain-containing protein	-
MMZ75_RS33945 (MMZ75_33955)	368514..368894	-	381	WP_001054412.1	hypothetical protein	-
MMZ75_RS33950 (MMZ75_33960)	368891..369217	-	327	WP_000091614.1	hypothetical protein	-
MMZ75_RS33955 (MMZ75_33965)	369241..369576	-	336	WP_000741275.1	hypothetical protein	-
MMZ75_RS33960 (MMZ75_33970)	369591..369926	-	336	WP_203788597.1	helix-turn-helix transcriptional regulator	Antitoxin
MMZ75_RS33965 (MMZ75_33975)	369907..370284	-	378	WP_203788600.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MMZ75_RS33970 (MMZ75_33980)	370476..371078	+	603	WP_010465829.1	recombinase family protein	-
MMZ75_RS33975 (MMZ75_33985)	371062..374091	+	3030	WP_010799689.1	Tn3 family transposase	-
MMZ75_RS33980 (MMZ75_33990)	374147..374902	+	756	WP_241474443.1	AraC family transcriptional regulator	-
MMZ75_RS33985 (MMZ75_33995)	374929..375081	-	153	WP_241474444.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..436805	436805

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-93)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13792.92 Da
• Isoelectric Point: 9.7862

>T237555 WP_203788600.1 NZ_CP093017:c370284-369907 [Pseudomonas aeruginosa]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAM
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKRNH

Nucleotide

• Length: 378 bp

>T237555 NZ_LR882497:1170427-1171308 [Mycobacterium tuberculosis variant microti]
GTGACCAAGCCCTATTCGTCGCCGCCAACGAACCTGCGCTCACTACGAGATCGGCTCACCCAAGTAGCGGAACGGCAAGG
TGTCGTGTTCGGTCGACTGCAGCGGCATGTCGCGATGATTGTTGTCGCACAGTTCGCGGCCACGCTCACCGACGACACCG
GCGCTCCGCTGCTGTTGGTCAAAGGCGGATCGTCGCTGGAACTGCGCCGGGGAATTCCCGATTCGCGGACCTCCAAAGAC
TTCGACACGGTCGCACGTCGCGATATCGAATTAATCCATGAACAGCTCGCTGACGCGGGCGAGACGGGGTGGGAAGGATT
CACTGCAATCTTCACCGCCCCCGAAGAAATCGATGTTCCTGGTATGCCGGTCAAGCCGCGCCGATTCACCGCCAAGCTGA
GCTACCGAGGCCGGGCTTTCGCAACTGTTCCGATCGAGGTCTCCTCCGTCGAAGCCGGCAATGCCGACCAATTCGACACC
CTCACCTCAGACGCGCTCGGCCTCGTGGGCGTACCCGCAGCAGTCGCCGTACCCTGCATGACCATTCCCTGGCAAATCGC
GCAGAAGCTGCACGCAGTAACTGCCGTGCTCGAAGAACCGAAGGTCAACGACCGCGCTCACGACCTGGTGGACTTGCAGC
TTCTTGAAGGACTGTTGCTCGATGCCGACCTCATGCCGACGCGCAGCGCGTGCATCGCGATATTCGAAGCGCGCGCCCAG
CATCCTTGGCCACCGAGAGTCGCCACGCTGCCGCACTGGCCGCTGATCTATGCAGGTGCGCTGGAGGGGCTTGACCACCT
TGAACTCGCCAGGACGGTCGACGCGGCGGCCCAGGCAGTGCAGCGATTCGTTGCGCGGATTGATCGGGCGACGAAAAGAT
GA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12102.25 Da
• Isoelectric Point: 10.3997

>AT237555 WP_203788597.1 NZ_CP093017:c369926-369591 [Pseudomonas aeruginosa]
MQKGIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Nucleotide

• Length: 336 bp

>AT237555 NZ_LR882497:1169807-1170430 [Mycobacterium tuberculosis variant microti]
TTGTGTGCAAAACCGTATCTAATTGATACGATTGCGCACATGGCTATCTGGGATCGCCTCGTCGAGGTTGCCGCCGAGCA
ACATGGCTACGTCACGACTCGCGATGCGCGAGACATCGGCGTCGACCCTGTGCAGCTCCGCCTCCTAGCGGGGCGCGGAC
GTCTTGAGCGTGTCGGCCGAGGTGTGTACCGGGTGCCCGTGCTGCCGCGTGGTGAGCACGACGATCTCGCAGCCGCAGTG
TCGTGGACTTTGGGGCGTGGCGTTATCTCGCATGAGTCGGCCTTGGCGCTTCATGCCCTCGCTGACGTGAACCCGTCGCG
CATCCATCTCACCGTCCCGCGCAACAACCATCCGCGTGCGGCCGGGGGCGAGCTGTACCGAGTTCACCGCCGCGACCTCC
AGGCAGCCCACGTCACTTCGGTCGACGGAATACCCGTCACGACGGTTGCGCGCACCATCAAAGACTGCGTGAAGACGGGC
ACGGATCCTTATCAGCTTCGGGCCGCGATCGAGCGAGCCGAAGCCGAGGGCACGCTTCGTCGTGGGTCAGCAGCTGAGCT
ACGCGCTGCGCTCGATGAGACCACTGCCGGATTACGCGCTCGGCCGAAGCGAGCATCGGCGTGA